EVI5L Inhibitors
EVI5L inhibitors encompass a range of compounds that can indirectly influence the function of EVI5L as a GTPase-activating protein. These modulators primarily target various aspects of GTPase signaling pathways, either by inhibiting specific GTPases or by affecting upstream or downstream components of these pathways. Inhibitors like NSC 23766 Trihydrochloride and ML 141 target specific GTPases such as Rac1 and Cdc42. By modulating these GTPases, these compounds can indirectly influence the broader signaling pathways in which EVI5L operates. Brefeldin A and SecinH3 affect the ARF GTPase family, either by disrupting GEF activity or inhibiting cytohesins. These alterations in GTPase signaling pathways can have downstream effects on the functions regulated by GTPase-activating proteins like EVI5L.
Statins, including Lovastatin and Simvastatin, and specific inhibitors like Farnesyltransferase Inhibitors (Tipifarnib) and Geranylgeranyltransferase Inhibitors (GGTI 298), impact the prenylation and localization of GTPases. Such modifications can indirectly affect the signaling pathways involving EVI5L. In summary, while direct inhibitors of EVI5L are not well-documented, the compounds listed provide avenues to modulate the GTPase pathways and related signaling mechanisms where EVI5L is involved. These inhibitors are valuable tools for investigating EVI5L's role in cellular signaling, providing insights into its biological functions.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Since EVI5 is known to regulate cell division and its localization is important for its function, staurosporine can inhibit EVI5 indirectly by altering the phosphorylation state of proteins that are required for EVI5's role in the cell cycle. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone is an anthracenedione antineoplastic agent. It intercalates into DNA and disrupts DNA replication and RNA synthesis. EVI5 has a role in chromosomal segregation; mitoxantrone can disrupt this process, leading to the functional inhibition of EVI5. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor. By inhibiting CDKs, this compound can alter the cell cycle checkpoints, potentially inhibiting EVI5's role in cell cycle regulation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a selective inhibitor of cyclin-dependent kinases. By inhibiting these kinases, the cell cycle can be halted, thereby inhibiting EVI5's involvement in cell cycle control. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavone that is known to have anti-proliferative effects. It can inhibit kinase activity and influence cell cycle progression, thereby indirectly inhibiting EVI5's functions related to cell division. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib is a receptor tyrosine kinase inhibitor. It can inhibit the signaling pathways that are critical for cell cycle progression and mitotic events where EVI5 is implicated. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib is a selective inhibitor of CDK4/6, crucial for cell cycle progression. By impeding the cell cycle, EVI5 function in mitotic processes is indirectly inhibited. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a checkpoint kinase inhibitor. It can disrupt the proper function of checkpoint kinases, which are vital for cell cycle control, where EVI5 plays a regulatory role. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
UCN-01 (7-hydroxystaurosporine) is a potent inhibitor of protein kinase C. It can affect the cell cycle and stress response pathways, potentially leading to the inhibition of EVI5's associated functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, it can modulate cell cycle progression and stress responses, indirectly leading to the functional inhibition of EVI5. | ||||||