EST-1 Inhibitors
EST-1 inhibitors are a class of compounds that specifically target the EST-1 enzyme, which is likely involved in a biological pathway related to esterase activity or similar hydrolytic processes. Esterases, including those in the EST family, play crucial roles in cellular metabolism by catalyzing the hydrolysis of ester bonds in various substrates. This enzymatic activity is important for processes such as lipid metabolism, detoxification, and the regulation of signal molecules. EST-1, as a specific member of this enzyme family, may have a specialized function in hydrolyzing specific ester-containing substrates. By inhibiting EST-1, researchers can investigate its particular role in cellular metabolism, providing insight into how the hydrolysis of ester bonds influences broader biochemical pathways.
The design of EST-1 inhibitors is typically based on their ability to bind to the enzyme's active site, blocking the interaction between the enzyme and its substrate. These inhibitors may contain chemical groups that mimic the structure of natural substrates or intermediates of the enzymatic reaction, allowing them to effectively compete for the active site. Some EST-1 inhibitors may act by forming covalent bonds with key residues in the enzyme, permanently inactivating it, while others may act reversibly, allowing for the controlled modulation of enzyme activity. The structural diversity of EST-1 inhibitors allows for selective targeting of the enzyme, which is critical for studying its specific functions without affecting other esterases or hydrolytic enzymes. Research into these inhibitors provides valuable insights into the regulation of metabolic pathways, enzymatic control mechanisms, and the role of ester bond hydrolysis in cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could downregulate EST-1 expression by inducing hyperacetylation of histones near the EST-1 promoter, thereby altering the accessibility of the DNA to transcription machinery. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By causing DNA demethylation, 5-Azacytidine might decrease the transcriptional repression of the EST-1 gene, leading to a reduction in its mRNA and protein levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D could bind specifically to the DNA at the start site of the EST-1 gene, stalling RNA polymerase and preventing the initiation of EST-1 mRNA synthesis. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A may specifically bind to DNA sequences in the EST-1 promoter region, blocking transcription factor binding and consequently decreasing EST-1 transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By specifically inhibiting mTOR, Rapamycin could decrease the transcription of the EST-1 gene as part of a wider response to reduced protein synthesis signaling. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin could selectively inhibit RNA polymerase II, which is responsible for mRNA synthesis, thereby decreasing the production of EST-1 mRNA transcripts. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
This compound could induce hyperacetylation of histones at the EST-1 gene locus, potentially leading to a tightly packed chromatin structure and reduced access for transcription factors, culminating in decreased EST-1 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could lead to the suppression of EST-1 expression by inhibiting the activity of DNA methyltransferases and histone acetyltransferases involved in the EST-1 gene regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could alter the transcription factor landscape, thereby decreasing the transcription of the EST-1 gene by changing the factors available to initiate its expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002, as a specific PI3K inhibitor, could downregulate the PI3K/Akt pathway and lead to a decrease in EST-1 gene expression through altered transcription factor activity. | ||||||