ERI-1 Inhibitors
ERI-1 inhibitors encompass a broad range of chemicals that exert their influence primarily by modifying the availability, processing, or stability of RNA substrates upon which ERI-1 can act. These compounds, such as α-Amanitin and Actinomycin D, either directly inhibit RNA polymerases or bind to DNA, leading to the disruption of RNA synthesis. This reduction in RNA synthesis indirectly impacts ERI-1's role in RNA degradation.
Other compounds, like Cordycepin and 5-Azacytidine, are nucleoside analogs that integrate into RNA chains. Their incorporation can affect the overall stability, processing, and structure of RNA, potentially altering the substrates available for ERI-1-mediated degradation. Additionally, compounds like Caffeine and Camptothecin might produce broader cellular effects that indirectly modulate RNA-centric pathways, further influencing ERI-1's activity. Together, these chemicals offer diverse mechanisms by which ERI-1's function in the cell can be modulated.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA and inhibits RNA synthesis. By affecting RNA synthesis, it can indirectly affect ERI-1's role in RNA degradation. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A potent inhibitor of RNA polymerase II, which could reduce the availability of RNA substrates for ERI-1 to act upon. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
This compound inhibits RNA polymerase II, potentially leading to a reduction in RNA substrates available for ERI-1 degradation. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
An adenosine analog that can terminate RNA chain elongation. Its integration into RNA chains can affect RNA stability and processing, potentially influencing ERI-1's RNA degradative activity. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
An antiviral nucleoside analog that can incorporate into RNA, affecting its processing and stability. Such alterations might affect the substrates available to ERI-1 for degradation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that can be incorporated into RNA, potentially affecting its stability and processing, thereby influencing the availability of RNA substrates for ERI-1 degradation. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
A guanine analog that can get incorporated into RNA molecules, potentially affecting RNA stability and processing. This can indirectly influence ERI-1's function. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
This compound interferes with RNA processing and stability, potentially modifying the number or type of RNA substrates available for ERI-1's degradative action. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Known to inhibit phosphodiesterases, its broad cellular effects might indirectly modulate RNA processing or degradation pathways, potentially affecting ERI-1's activity. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $53.00 $91.00 $169.00 $474.00 | 8 | |
As an RNA modification, it can influence RNA stability and interactions. Such modifications might modify the RNA substrates available or the efficiency of ERI-1-mediated degradation. | ||||||