ER81 Activators
ER81, also known as ETS-related protein 81, is a transcription factor encoded by the ER81 gene. It belongs to the ETS (E26 transformation-specific) family of transcription factors, which are crucial regulators of gene expression involved in various cellular processes such as proliferation, differentiation, apoptosis, and development. ER81 plays a significant role in the regulation of gene expression during embryonic development, particularly in the development of the central nervous system, skeletal muscle, and other tissues. It functions by binding to specific DNA sequences within the regulatory regions of target genes, thereby modulating their transcriptional activity.
Activation of ER81 involves intricate signaling pathways and mechanisms that regulate its transcriptional activity. Several signaling cascades, including growth factor signaling pathways such as the MAPK/ERK pathway and the PI3K/Akt pathway, are known to influence ER81 activity. Upon activation of these pathways, downstream effectors phosphorylate ER81, leading to its nuclear translocation and binding to target gene promoters. Additionally, ER81 activation can be modulated by various co-factors and interaction partners, which regulate its DNA-binding affinity and transcriptional activity. Furthermore, post-translational modifications such as phosphorylation, acetylation, and methylation play crucial roles in fine-tuning ER81 activity in response to cellular stimuli. Overall, the activation of ER81 is tightly regulated by complex signaling networks and molecular interactions, ensuring precise control of gene expression patterns during development and in response to environmental cues.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, an adenylate cyclase activator, directly activates ER81 by influencing the cAMP/PKA signaling pathway. By stimulating adenylate cyclase, Forskolin increases cAMP levels, leading to the activation of protein kinase A (PKA) and subsequent modulation of ER81 activity. This direct activation highlights the role of cAMP-dependent signaling in regulating ER81 and its involvement in cellular processes influenced by ER81. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, an SIRT1 activator, indirectly activates ER81 by modulating the SIRT1/FOXO1 signaling pathway. Through activation of SIRT1, Resveratrol influences the deacetylation of FOXO1, leading to its translocation to the nucleus and subsequent modulation of ER81 activity. This indirect activation underscores the interconnectedness of signaling pathways and the role of SIRT1 in regulating ER81 function through epigenetic modifications. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP, a cell-permeable cAMP analog, directly activates ER81 by mimicking the effects of cAMP and influencing the cAMP/PKA signaling pathway. By bypassing adenylate cyclase, Dibutyryl cAMP increases intracellular cAMP levels, leading to the activation of PKA and subsequent modulation of ER81 activity. This direct activation highlights the specific role of cAMP signaling in regulating ER81 and its impact on cellular processes controlled by ER81. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a PKC activator, indirectly activates ER81 by modulating the PKC signaling pathway. Through activation of PKC, PMA influences downstream signaling events that intersect with ER81 regulation, illustrating the interconnectedness of signaling pathways in influencing ER81 activity. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMP-activated protein kinase (AMPK) activator, indirectly activates ER81 by modulating the AMPK signaling pathway. Through activation of AMPK, A769662 influences downstream signaling events that intersect with ER81 regulation, illustrating the interconnectedness of signaling pathways in influencing ER81 activity. This indirect activation underscores the role of AMPK-mediated signaling in modulating ER81 function and its involvement in cellular processes controlled by ER81. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Cyclic AMP, a second messenger, directly activates ER81 by influencing the cAMP/PKA signaling pathway. Through the activation of PKA, cAMP directly modulates ER81 activity, providing a link between second messenger signaling and the regulation of ER81 in cellular contexts. This direct activation underscores the specific role of cAMP signaling in regulating ER81 and its impact on cellular processes controlled by ER81. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, an HDAC inhibitor, indirectly activates ER81 by influencing chromatin structure. By inhibiting HDAC, Sodium Butyrate increases histone acetylation, leading to a more open chromatin conformation and subsequent modulation of ER81 activity. This indirect activation emphasizes the role of epigenetic modifications in regulating ER81 and its involvement in cellular processes influenced by ER81. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMP-activated protein kinase (AMPK) activator, indirectly activates ER81 by modulating the AMPK signaling pathway. Through activation of AMPK, AICAR influences downstream signaling events that intersect with ER81 regulation, illustrating the interconnectedness of signaling pathways in influencing ER81 activity. This indirect activation underscores the role of AMPK-mediated signaling in modulating ER81 function and its involvement in cellular processes controlled by ER81. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
Also called SC79, this compound, an Akt activator, indirectly activates ER81 by modulating the PI3K/AKT signaling pathway. Through activation of Akt, SC79 influences downstream signaling events that intersect with ER81 regulation, illustrating the interconnectedness of signaling pathways in influencing ER81 activity. This indirect activation emphasizes the role of PI3K/AKT-mediated signaling in modulating ER81 function and its involvement in cellular processes controlled by ER81. | ||||||