ephrin-A5 Activators
ephrin-A5 Activators are not defined by a single chemical class but are rather characterized by their ability to modulate the pathways that indirectly activate or enhance the signaling of ephrin-A5. These activators influence a variety of cellular mechanisms that include increasing the expression of Eph receptors, the natural binding partners for ephrin-A5, or activating signaling cascades that result in the phosphorylation and activation of these receptors. Upregulation of receptor tyrosine kinases such as the Eph family can have cascading effects on cellular adhesion, morphology, and migration, processes in which ephrin-A5 is intimately involved.
The indirect activators of ephrin-A5 may act by modulating the levels of intracellular messengers such as calcium or cAMP, influencing gene expression through retinoid pathways, or by affecting protein kinase C activity. GPCR ligands can trigger phosphorylation events that ultimately enhance Eph receptor signaling, and the presence of glycosaminoglycans can affect the interaction dynamics between ephrin-A5 and its receptors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophores raise intracellular calcium levels, which can enhance Eph receptor kinase activity, thereby potentially increasing ephrin-A5 signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C which can lead to the phosphorylation and activation of Eph receptors, thereby enhancing ephrin-A5 signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence the expression levels of Eph receptors, possibly leading to enhanced ephrin-A5 signaling through increased ligand-receptor interactions. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P receptor signaling can lead to the activation of Eph receptors, which may result in the potentiation of ephrin-A5 signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises cAMP levels, which may lead to the activation of Eph receptors and enhance ephrin-A5-mediated signaling through downstream effects. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can modulate Eph receptor activity, and therefore, it can indirectly increase ephrin-A5 signaling. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine modulates the Hedgehog signaling pathway, which has been implicated in the regulation of Eph receptor expression, potentially influencing ephrin-A5 activity. | ||||||