ephrin-A5 Inhibitors
The chemicals classified as ephrin-A5 Inhibitors engage in diverse modes of action to interfere with the activity of ephrin-A5, focusing primarily on altering the signaling pathways associated with ephrin-A5. These inhibitors can indirectly influence the biological activities of ephrin-A5 by modulating the signal transduction processes that govern the functionality of ephrin-A5 in cellular communication and migration. They operate by impeding the kinases responsible for Eph receptor phosphorylation, thus inhibiting the propagation of signals that would normally be triggered by ephrin-A5. Through the inhibition of key signaling molecules like Protein Kinase C, MAPK/ERK, and PI3K, these compounds can alter the cellular response to ephrin-A5 engagement, thereby modulating the biological outcome.
Ephrin-A5 inhibitors also impact the synthesis of proteins and other molecules that are vital to the interaction between ephrin-A5 and Eph receptors, such as the effects observed with cycloheximide and chlorate. By disrupting glycosaminoglycan synthesis, for example, the structural basis for ephrin-A5 interaction with its receptors can be affected, which in turn influences the downstream signaling events
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor which inhibits Eph receptor activity, consequently attenuating the downstream signaling initiated by ephrin-A5 binding. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 inhibits Protein Kinase C, which is involved in Eph receptor activation, and can suppress the downstream signaling of ephrin-A5. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, reducing Eph receptor activation and the subsequent signaling of ephrin-A5 by affecting the PI3K/AKT pathway. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
BAPTA acts as a calcium chelator, disrupting calcium-dependent activation of Eph receptors and the signaling cascade of ephrin-A5. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
By inhibiting protein synthesis, cycloheximide can reduce Eph receptor expression and inhibit ephrin-A5 signaling. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram inhibits aldehyde dehydrogenase, leading to decreased synthesis of retinoic acid which may affect Eph receptor expression and ephrin-A5 signaling. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib inhibits the Hedgehog signaling pathway, which can decrease the expression of Eph receptors and impact ephrin-A5 signaling. | ||||||
Sodium chlorate | 7775-09-9 | sc-212938 | 100 g | $59.00 | 1 | |
Chlorate inhibits glycosaminoglycan synthesis, potentially modifying interactions between ephrin-A5 and Eph receptors and influencing signaling. | ||||||
SKI II | 312636-16-1 | sc-204286 sc-204286A | 10 mg 50 mg | $96.00 $400.00 | 3 | |
SKI-II targets sphingosine kinase, which may modulate S1P receptor signaling, affecting Eph receptor activity and ephrin-A5 signaling. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 inhibits PKA, which could lead to reduced Eph receptor phosphorylation and thereby influence ephrin-A5 signaling. | ||||||