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Enterokinase HC Inhibitors

Enterokinase HC inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of enterokinase, a serine protease enzyme predominantly found in the brush border of the small intestine. Enterokinase plays a critical role in the activation of digestive enzymes, particularly by converting the inactive zymogen trypsinogen into its active form, trypsin. The inhibitors in this class are structurally diverse and can be designed to bind to the active site of enterokinase, effectively preventing its interaction with trypsinogen. This blockade is crucial in regulating proteolytic cascades in the digestive process. The molecular architecture of enterokinase HC inhibitors often includes a high degree of specificity for the enzyme's active site, featuring moieties that mimic the natural substrates of enterokinase, thus achieving competitive inhibition. Additionally, the design of these inhibitors may involve peptide-based analogs, small molecules, or even macromolecules that can effectively occupy the active site or alter the enzyme's conformation. The study and development of enterokinase HC inhibitors are heavily rooted in structural biology and biochemistry. Researchers employ various techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and molecular docking studies to elucidate the precise binding interactions between the inhibitors and enterokinase. By understanding these interactions at the atomic level, scientists can fine-tune the inhibitory potency and selectivity of these compounds. Moreover, the synthesis of enterokinase HC inhibitors may involve sophisticated organic chemistry approaches, including solid-phase peptide synthesis for peptide-based inhibitors or combinatorial chemistry for small-molecule inhibitors. The inhibitors' effectiveness can be evaluated through in vitro assays that measure the enzymatic activity of enterokinase in the presence of these compounds, providing insight into their inhibitory mechanisms and potential applications in regulating enzymatic activity within biological systems.

Items 1 to 10 of 12 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Triptolide	38748-32-2	sc-200122 sc-200122A	1 mg 5 mg	$90.00 $204.00	13	(1)
Triptolide may downregulate the transcriptional machinery by inhibiting the activity of RNA polymerase II, potentially leading to a decrease in Enterokinase HC mRNA synthesis and subsequent protein expression.
Rapamycin	53123-88-9	sc-3504 sc-3504A sc-3504B	1 mg 5 mg 25 mg	$63.00 $158.00 $326.00	233	(4)
Rapamycin selectively targets and inhibits mTORC1, which is crucial for cap-dependent translation initiation; this action could result in a decreased rate of Enterokinase HC protein synthesis.
5-Azacytidine	320-67-2	sc-221003	500 mg	$280.00	4	(1)
By incorporating into DNA and inhibiting DNA methyltransferases, 5-Azacytidine could lead to hypomethylation and the consequent transcriptional de-silencing of genes that can downregulate Enterokinase HC expression.
Trichostatin A	58880-19-6	sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D	1 mg 5 mg 10 mg 25 mg 50 mg	$152.00 $479.00 $632.00 $1223.00 $2132.00	33	(3)
Trichostatin A may inhibit histone deacetylase, leading to a hyperacetylated chromatin state that could decrease transcription of certain genes, possibly including those encoding Enterokinase HC.
Curcumin	458-37-7	sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E	1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg	$37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00	47	(1)
Curcumin has been shown to downregulate the expression of specific genes involved in the inflammatory response, and it could hypothetically reduce Enterokinase HC expression by altering the transcription of genes within its regulatory network.
Resveratrol	501-36-0	sc-200808 sc-200808A sc-200808B	100 mg 500 mg 5 g	$80.00 $220.00 $460.00	64	(2)
Resveratrol has the potential to inhibit the expression of genes involved in the cell cycle and proliferation pathways, which might result in a reduction of Enterokinase HC protein levels as a downstream effect.
Sodium Butyrate	156-54-7	sc-202341 sc-202341B sc-202341A sc-202341C	250 mg 5 g 25 g 500 g	$31.00 $47.00 $84.00 $222.00	19	(3)
Sodium butyrates inhibition of histone deacetylase can lead to the upregulation of genes that suppress or downregulate the expression of other genes, potentially including those coding for Enterokinase HC.
Chloroquine	54-05-7	sc-507304	250 mg	$69.00	2	(0)
Chloroquine disrupts lysosomal acidification and could thereby inhibit the proteolytic processing of transcription factors that are essential for Enterokinase HC expression, leading to its reduced synthesis.
(−)-Epigallocatechin Gallate	989-51-5	sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E	10 mg 50 mg 100 mg 500 mg 1 g 10 g	$43.00 $73.00 $126.00 $243.00 $530.00 $1259.00	11	(1)
This compound could decrease Enterokinase HC expression by inhibiting the activity of DNA methyltransferases and histone acetyltransferases, which are enzymes involved in the epigenetic regulation of gene expression.
Retinoic Acid, all trans	302-79-4	sc-200898 sc-200898A sc-200898B sc-200898C	500 mg 5 g 10 g 100 g	$66.00 $325.00 $587.00 $1018.00	28	(1)
Retinoic Acid can induce the differentiation of various cell types and, in doing so, could downregulate the expression of genes that are not associated with the differentiated state, potentially including Enterokinase HC.

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Enterokinase HC Inhibitors

Triptolide

Rapamycin

5-Azacytidine

Trichostatin A

Curcumin

Resveratrol

Sodium Butyrate

Chloroquine

(−)-Epigallocatechin Gallate

Retinoic Acid, all trans