ENHO Activators
ENHO Activators predominantly modulate specific cellular pathways to amplify the transcription or function of the ENHO protein. Compounds like Forskolin, IBMX, and Isoproterenol are designed to elevate intracellular cAMP levels. Forskolin operates by directly stimulating adenylate cyclase, while IBMX exerts its effects by inhibiting phosphodiesterase, which normally breaks down cAMP. The elevated cAMP levels activate Protein Kinase A (PKA), which then phosphorylates the transcription factor CREB. Once phosphorylated, CREB promotes the transcription of the ENHO gene.
On another front, AICAR and Metformin target the AMPK pathway to subsequently activate the coactivator PGC-1α, which has a pivotal role in upregulating ENHO. Similarly, Oleic Acid and Palmitoylethanolamide activate the PPAR-alpha pathway, enhancing ENHO transcription. Other activators like Retinoic Acid act by directly influencing nuclear receptors such as the retinoic acid receptor, which binds to the retinoic acid response elements in the ENHO gene, ultimately promoting its transcription. By understanding the specific pathways that these activators target, precise and controlled activation of ENHO can be achieved.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases intracellular cAMP levels, directly promoting PKA activation and CREB phosphorylation, enhancing ENHO gene transcription. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Raises intracellular cAMP levels by inhibiting phosphodiesterase, promoting CREB activation and thus ENHO gene transcription. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Acts as a Beta-adrenergic receptor agonist; increases cAMP levels, leading to CREB pathway activation and ENHO gene transcription. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Directly activates AMPK pathway, promoting activation of PGC-1α, enhancing ENHO expression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Activates AMPK, leading to subsequent activation of PGC-1α, which enhances ENHO expression. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Activates PPAR-alpha, which then translocates to the nucleus and enhances ENHO gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Acts as an HDAC inhibitor, causing chromatin relaxation, thus promoting ENHO transcription. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Activates TRPV1, which can increase intracellular Ca2+ levels, leading to activation of CREB and thus ENHO transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Activates the retinoic acid receptor, which binds to retinoic acid elements in the ENHO gene, promoting transcription. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A membrane-permeable form of cAMP that activates PKA and CREB, directly enhancing ENHO gene transcription. | ||||||