ENGase Activators
Endo-β-N-acetylglucosaminidase (ENGase) is an enzyme that plays a significant role in the processing of N-linked glycoproteins, which are proteins modified by the attachment of a carbohydrate molecule. This post-translational modification is critical for protein folding, stability, and function.ENGase specifically cleaves between two GlcNAc residues in the chitobiose core of the N-glycan, releasing an intact glycan and a protein with a single GlcNAc residue remaining. This unique cleavage activity distinguishes ENGase from other glycosidases.
In humans, there are two types of ENGase: cytosolic ENGase and glycoside hydrolase family 18 ENGase. The former is involved in the degradation of misfolded glycoproteins through a process called ER-associated degradation (ERAD). The latter is known to act more broadly in the hydrolysis of N-linked glycansMutations in the genes encoding ENGase have been linked to various diseases. For instance, a mutation in the gene encoding cytosolic ENGase has been associated with a form of hereditary inclusion body myopathy, an autosomal recessive muscle disorder characterized by muscle weakness and wasting.Their ability to cleave N-linked glycans is utilized in the production of glycoprotein drugs and the investigation of N-glycan structures.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An inhibitor of N-linked glycosylation, potentially increasing stress on the ER and indirectly influencing ENGase activity by upregulating the deglycosylation process. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $135.00 $246.00 $619.00 $799.00 $1796.00 | 6 | |
An inhibitor of Golgi alpha-mannosidase II, potentially altering glycoprotein processing and indirectly affecting ENGase activity. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
An inhibitor of glucosidase I and II, affecting N-linked glycosylation and potentially influencing ENGase activity in protein processing. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $72.00 $142.00 | ||
An inhibitor of alpha-glucosidase, potentially impacting N-linked glycosylation and thereby influencing ENGase activity. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $132.00 $529.00 $1005.00 $6125.00 | 25 | |
An inhibitor of mannosidase I, affecting the processing of high mannose-type N-glycans, potentially influencing ENGase activity. | ||||||
Deoxymannojirimycin hydrochloride | 84444-90-6 | sc-201360 sc-201360A | 1 mg 5 mg | $93.00 $239.00 | 2 | |
An inhibitor of mannosidase I, altering N-glycan processing, potentially affecting ENGase activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts ER to Golgi transport, potentially causing ER stress and influencing ENGase activity as a response to altered glycoprotein trafficking. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor, potentially leading to increased ER stress and possibly enhancing ENGase activity due to accumulated misfolded glycoproteins. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Raises lysosomal pH, potentially affecting lysosomal degradation pathways and indirectly influencing ENGase activity in glycoprotein processing. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Inhibits ER-associated degradation (ERAD), potentially increasing misfolded glycoprotein levels and indirectly influencing ENGase activity. | ||||||