EMR3 Inhibitors
Chemical inhibitors of EMR3 can modulate its function through various biochemical pathways, each targeting different aspects of the protein's signaling mechanisms. WZ4003, as a selective NUAK kinase inhibitor, can disrupt the kinase-dependent cellular adhesion and migration processes that are critical for EMR3's role on the cell surface. Similarly, the Src family kinase inhibitor PP2 can dampen EMR3 signaling by blocking the kinase activity necessary for downstream signal transduction. Pertussis Toxin, known for its inhibition of G(i) proteins, can prevent the coupling of EMR3 to its G-protein-mediated signaling cascade, effectively silencing the cellular responses typically propagated by EMR3 activation.
Further along the cascade of intracellular events influenced by EMR3, LY294002, which inhibits phosphoinositide 3-kinases (PI3K), can obstruct the PI3K signaling pivotal for various EMR3-related cellular processes. U73122's role as a phospholipase C inhibitor means it can disrupt the generation of diacylglycerol and inositol trisphosphate, both of which serve as second messengers in EMR3's signaling pathways. Go 6983 and Chelerythrine, as inhibitors of protein kinase C (PKC), can prevent the phosphorylation events that are vital for the regulatory functions of EMR3. Y-27632, by inhibiting ROCK, affects the actin cytoskeleton dynamics, consequently impairing the trafficking and membrane expression of EMR3. ML7's inhibition of myosin light chain kinase also impacts cytoskeletal reorganization, which is crucial for the cellular processes dependent on EMR3 signaling. PD 98059 and SB 203580 target the MAP kinase pathways, with PD 98059 inhibiting the MEK/ERK pathway and SB 203580 targeting the p38 MAP kinase pathway, both of which are likely involved in the functional activity of EMR3. Finally, BAPTA-AM, by chelating intracellular calcium, can interfere with the calcium-dependent signaling processes integral to EMR3's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
WZ4003 is a selective NUAK kinase inhibitor. Given the role of NUAK family kinases in cellular adhesion and migration processes, inhibiting these kinases could lead to functional inhibition of EMR3 by disrupting cell surface interactions and EMR3-mediated signaling, which are crucial for EMR3's role in immune cell migration and adhesion. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor. EMR3, being a GPCR involved in immune response, is likely to interact with Src family kinases for downstream signaling. Inhibition of these kinases by PP2 can lead to decreased EMR3 signaling, thereby functionally inhibiting EMR3 by preventing its signal transduction. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K signaling is integral to various cellular processes including those influenced by GPCRs like EMR3. Inhibiting PI3K can impair downstream signaling required for EMR3's functional activity, thus functionally inhibiting EMR3. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin is an inhibitor of G(i) proteins. By inhibiting G(i) proteins, Pertussis Toxin can functionally inhibit EMR3 by preventing G-protein mediated signal transduction that is essential for EMR3's role in immune cell signaling and function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a pan-protein kinase C (PKC) inhibitor. Since PKC is involved in signaling pathways that include GPCR-mediated activities, inhibiting PKC can lead to functional inhibition of EMR3 by preventing its role in cell signaling and immune responses. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. ROCK is involved in regulating actin cytoskeleton dynamics, which is crucial for the trafficking and expression of GPCRs like EMR3. Inhibition of ROCK by Y-27632 can lead to functional inhibition of EMR3 by impairing its proper localization and function in the cell membrane. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML7 is a myosin light chain kinase inhibitor. Myosin light chain kinase plays a role in cytoskeletal rearrangements, which are important for GPCR-mediated cellular responses. Inhibition of this kinase can inhibit EMR3 function by disrupting cellular processes that are dependent on EMR3 signaling, particularly in immune cells. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MAP kinase/ERK kinase (MEK). Inhibition of MEK can disrupt ERK-mediated signaling pathways, which may be necessary for EMR3 mediated functions in immune response regulation. Therefore, PD 98059 can contribute to the functional inhibition of EMR3 by blocking these downstream signaling events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAP kinase inhibitor. The p38 MAP kinase pathway is involved in inflammatory responses, and GPCRs like EMR3 are known to play roles in immune cell function. SB 203580 can functionally inhibit EMR3 by blocking the p38 MAP kinase pathway, which is potentially involved in EMR3-mediated cellular responses. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC). Since EMR3 is a GPCR that could interact with PKC in its signaling pathways, chelerythrine can lead to functional inhibition of EMR3 by impeding PKC-mediated phosphorylation events that are vital for EMR3's function in immune cell signaling. | ||||||