EML4 Activators
EML4 Activators is a chemical class of compounds that primarily function as modulators of the EML4 protein, also known as echinoderm microtubule-associated protein-like 4. EML4 is a cytoskeletal protein that plays a crucial role in cellular processes related to microtubules, which are dynamic filaments involved in various cellular functions, including intracellular transport, cell division, and maintenance of cell shape. The activation of EML4 by these compounds can have significant implications for cellular physiology and signal transduction pathways.
These activators are designed to interact with EML4 in a way that enhances its function, promoting microtubule stability and influencing microtubule organization within the cell. By binding to EML4, they can impact the dynamics of microtubules, which are essential for processes such as cell division and intracellular trafficking. This modulation of EML4 activity can have downstream effects on cellular processes that rely on the microtubule cytoskeleton, ultimately influencing cell shape, movement, and the distribution of cellular components. Moreover, the specific mechanisms by which EML4 activators interact with this protein may vary, and the chemical class likely includes diverse compounds with distinct modes of action. Understanding the precise mechanisms of EML4 activation and its downstream effects on cellular processes can shed light on fundamental cell biology and may have implications for various fields of research, including cancer biology, neurobiology, and cell development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules by binding to them, affecting microtubule dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, potentially affecting microtubule-associated functions of EML4. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine interferes with microtubule assembly and dynamics, potentially impacting EML4-mediated microtubule regulation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine disrupts microtubule function, potentially influencing EML4-associated microtubule processes. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules, similar to paclitaxel, and may indirectly affect EML4 by modulating microtubule dynamics. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin inhibits microtubule formation, potentially influencing EML4-mediated microtubule processes. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Phosphatase inhibitors like okadaic acid can modulate signaling pathways that indirectly affect EML4 activity. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Some kinase inhibitors, like erlotinib, can affect EML4 activity by altering downstream signaling pathways. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $67.00 $159.00 $312.00 $928.00 $1856.00 $6706.00 | 7 | |
Tubulin-binding agents like colcemid may interfere with EML4-microtubule interactions, affecting EML4 function. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic trioxide can modulate signaling pathways involved in EML4 regulation indirectly through cellular signaling processes. | ||||||