EMILIN-2 Inhibitors
EMILIN-2 inhibitors represent a distinctive class of chemical compounds designed to modulate the activity of the Extracellular Matrix-Induced Lysyl oxidase Inhibitor-2 (EMILIN-2). EMILIN-2 is a glycoprotein belonging to the EMILIN family, renowned for its crucial role in maintaining the structural integrity and elasticity of various tissues. This family of glycoproteins is primarily associated with extracellular matrix (ECM) organization, influencing cell adhesion, migration, and tissue homeostasis. Within this context, EMILIN-2 inhibitors are meticulously engineered molecules aimed at regulating the function of EMILIN-2, thereby exerting a profound impact on the intricate balance of the extracellular matrix.
EMILIN-2 inhibitors are characterized by their affinity for specific binding sites on EMILIN-2, disrupting its normal interactions within the ECM. These inhibitors often possess unique molecular motifs that enable them to selectively target EMILIN-2, modulating its function without affecting the activity of other extracellular matrix components. The development of EMILIN-2 inhibitors stems from a growing understanding of the physiological importance of EMILIN-2 in tissue maintenance and repair processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can interfere with tyrosine kinases, which may affect integrin signaling, potentially altering EMILIN2's interaction with the ECM. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor which can alter integrin-mediated signaling pathways, potentially affecting EMILIN2's role in ECM organization. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, which is involved in many signaling pathways, including those related to integrin signaling, potentially influencing EMILIN2's function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor that can modulate downstream effects of integrin signaling, possibly affecting EMILIN2's ECM interactions. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide is an integrin inhibitor that targets the fibronectin receptor, which could alter EMILIN2's interaction with ECM. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which acts upstream of ERK in the MAPK pathway, potentially impacting pathways involving EMILIN2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which can modulate integrin signals, potentially affecting EMILIN2's ECM organization role. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad spectrum tyrosine kinase inhibitor that can affect integrin signaling pathways, potentially influencing EMILIN2-related processes. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor, which may affect ECM remodeling and indirectly influence EMILIN2's function. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
Tyrphostin AG 1478 is an EGFR tyrosine kinase inhibitor that could indirectly influence integrin-mediated signaling pathways involving EMILIN2. | ||||||