EMILIN-2 Antibody (3D9): sc-517180

EMILIN-2 Antibody (3D9) is a mouse monoclonal IgG3 kappa light chain antibody that detects EMILIN-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-EMILIN-2 antibody (3D9) is available as a non-conjugated monoclonal isotype antibody. EMILIN-2, a member of the elastin microfibril interface located proteins, plays a crucial role in the extracellular matrix, particularly in elastogenesis, which is the formation of elastic fibers essential for structural integrity and elasticity of tissues. EMILIN-2 is characterized by a unique proline-rich domain, which distinguishes EMILIN-2 from other EMILIN family members and suggests a specialized function in elastic fiber assembly and maintenance. EMILIN-2 is particularly significant in elastin-rich tissues such as blood vessels, skin, heart, and lung, where EMILIN-2 contributes to mechanical properties and resilience of these structures. EMILIN-2 interacts with various proteins, including fibulin-5, which is involved in elastin assembly regulation, further underscoring EMILIN-2′s importance in connective tissue biology. Understanding EMILIN-2′s role and interactions can provide insights into developmental processes and potential implications in diseases characterized by connective tissue abnormalities.

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EMILIN-2 Antibody (3D9) References:

1. EMILIN, a component of the elastic fiber and a new member of the C1q/tumor necrosis factor superfamily of proteins.  |  Doliana, R., et al. 1999. J Biol Chem. 274: 16773-81. PMID: 10358019
2. Self-assembly and supramolecular organization of EMILIN.  |  Mongiat, M., et al. 2000. J Biol Chem. 275: 25471-80. PMID: 10821830
3. Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily.  |  Doliana, R., et al. 2001. J Biol Chem. 276: 12003-11. PMID: 11278945
4. beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain.  |  Spessotto, P., et al. 2003. J Biol Chem. 278: 6160-7. PMID: 12456677
5. Expression of the EMILIN-1 gene during mouse development.  |  Braghetta, P., et al. 2002. Matrix Biol. 21: 603-9. PMID: 12475644
6. EMILIN-1 deficiency induces elastogenesis and vascular cell defects.  |  Zanetti, M., et al. 2004. Mol Cell Biol. 24: 638-50. PMID: 14701737
7. Molecular cloning and characterization of a novel gene, EMILIN-5, and its possible involvement in skeletal development.  |  Doi, M., et al. 2004. Biochem Biophys Res Commun. 313: 888-93. PMID: 14706625
8. Sequence-specific backbone NMR assignments for the C-terminal globular domain of EMILIN-1.  |  Verdone, G., et al. 2004. J Biomol NMR. 29: 91-2. PMID: 15017143
9. C1q and tumor necrosis factor superfamily: modularity and versatility.  |  Kishore, U., et al. 2004. Trends Immunol. 25: 551-61. PMID: 15364058
10. Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes.  |  Scavello, GS., et al. 2005. Mol Vis. 11: 97-110. PMID: 15723005
11. Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix.  |  Schiavinato, A., et al. 2016. J Invest Dermatol. 136: 1150-1160. PMID: 26945878
12. Emilin-2 is a component of bone marrow extracellular matrix regulating mesenchymal stem cell differentiation and hematopoietic progenitors.  |  Da Ros, F., et al. 2022. Stem Cell Res Ther. 13: 2. PMID: 35012633

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EMILIN-2 Antibody (3D9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-EMILIN-2 Antibody (3D9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EMILIN-2 Antibody (3D9) Specifications

Alternate Product Name: EMILIN-2

Product Clone Name: 3D9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 121-230

Epitope Target: EMILIN-2

Epitope Species: human

Product Reactivity/Detection: EMILIN-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for EMILIN-2 Antibody (3D9): N/A