EMILIN-2 Activators
EMILIN-2 activators are a series of chemical compounds that indirectly influence the functional activity of EMILIN-2 through their effects on the extracellular matrix (ECM) and collagen synthesis, stabilization, and remodeling. Ascorbic Acid plays a pivotal role in collagen synthesis by enhancing hydroxylation reactions, which can indirectly augment the integration and function of EMILIN-2 in the ECM. Copper(II) sulfate and Manganese(II) chloride, acting as cofactors for lysyl oxidase and prolidase respectively, are integral to the enzymatic processes that stabilize and remodel the ECM, thus potentiating the environment where EMILIN-2 exerts its effects. Similarly, Genipin's ability to cross-link proteins within the ECM could enhance EMILIN-2's role in matrix stabilization. Additionally, Estradiol's influence on the synthesis of ECM proteins create favorable conditions for EMILIN-2 to perform its structural role, while D-Penicillamine's action on disulfide bonds in collagen might lead to an altered matrix that could necessitate the adaptive enhancement of EMILIN-2's organizational activity.
The modulation of ECM interactions and cell behaviors by Lysophosphatidic Acid could indirectly lead to a matrix that supports EMILIN-2's functional activity. Zinc Chloride's role as a cofactor for MMPs that remodel the ECM can also indirectly influence the ECM and hence the activity of EMILIN-2. The provision of Hydroxyproline, a major component of collagen, supports collagen synthesis and stabilization, which is likely to indirectly enhance EMILIN-2's function within the ECM. Calcium Chloride, by reinforcing calcium-dependent interactions, ensures a robust ECM, creating a conducive environment for EMILIN-2 activity. Lastly, N-Acetylglucosamine, by fueling hyaluronan synthesis, plays a crucial role in ECM assembly, facilitating an enhanced functional role for EMILIN-2 in maintaining ECM integrity and stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic Acid is known to enhance hydroxylation reactions, which are important for the maturation of collagen. EMILIN-2, being involved in the organization of the extracellular matrix, could be affected by increased collagen synthesis, thereby possibly enhancing its functional activity in the matrix stabilization. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
As a cofactor for lysyl oxidase, a collagen cross-linking enzyme, Copper(II) sulfate is essential for the enzymatic activity that leads to the stabilization of the extracellular matrix where EMILIN-2 is located. By promoting collagen cross-linking, it may enhance the structural integrity of the matrix, indirectly supporting EMILIN-2's function. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is a cofactor for enzymes such as prolidase, which is involved in collagen turnover and matrix remodeling. By enhancing prolidase activity, Manganese(II) chloride could contribute to a matrix environment that supports EMILIN-2's structural role. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences cellular differentiation and extracellular matrix production. By promoting a differentiated state in cells that produce components of the matrix, it could enhance the functional integration of EMILIN-2 into the matrix. | ||||||
Genipin | 6902-77-8 | sc-203057 sc-203057A | 25 mg 100 mg | $82.00 $246.00 | 6 | |
Genipin cross-links amino acids in proteins, thus it may strengthen the extracellular matrix by cross-linking molecules adjacent to EMILIN-2, potentially enhancing its stabilizing effect on the matrix. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol has been shown to influence the synthesis of extracellular matrix proteins. By upregulating the synthesis of matrix components, it could create an environment where EMILIN-2 is more functionally active. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Penicillamine works by breaking disulfide bonds in collagen, leading to a change in the extracellular matrix. This alteration could potentially enhance the role of EMILIN-2 in matrix organization as the matrix adapts to these changes. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Lysophosphatidic Acid is a bioactive lipid that can influence cell migration and extracellular matrix interactions. By altering cell behaviors, it could modify the matrix in a way that enhances the activity of EMILIN-2. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor for matrix metalloproteinases (MMPs) which remodel the extracellular matrix. By modulating MMP activity, Zinc Chloride may influence the matrix environment and thus the function of EMILIN-2. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions are crucial for the integrity of the extracellular matrix and cell adhesion. By enhancing calcium-dependent adhesive interactions, Calcium Chloride could improve the structural context in which EMILIN-2 operates. | ||||||