EG666806 Activators
Eukaryotic translation initiation factor 1A domain containing 8 Activators are a diverse group of compounds that enhance the protein's function in mRNA translation initiation. By acting on different signaling pathways, these activators ultimately promote the formation and stability of the translation initiation complex, which is central to the synthesis of proteins. For example, compounds that increase intracellular cAMP levels, such as forskolin, isoproterenol, rolipram, caffeine, BAY 60-7550, and dibutyryl-cAMP, activate protein kinase A (PKA). PKA can then phosphorylate specific translation initiation factors, leading to enhanced activity of EIF1AD8 by facilitating ribosomal assembly and mRNA recruitment.
Moreover, by modulating cellular calcium levels and the PI3K/Akt/mTOR pathway, compounds like ionomycin and LY294002 indirectly influence EIF1AD8 activity. Ionomycin's elevation of intracellular calcium activates calmodulin-dependent kinases, enhancing EIF1AD8's role in the translation initiation process. On the other hand, LY294002's inhibition of PI3K and rapamycin's inhibition of mTOR alleviate inhibitory controls on translation initiation, promoting EIF1AD8's involvement in this fundamental cellular process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as an ionophore that selectively binds and transports calcium ions across cell membranes. The resultant increase in intracellular calcium can activate calmodulin-dependent pathways, potentially enhancing the phosphorylation and activity of factors involved in translation initiation, including Eukaryotic translation initiation factor 1A domain containing 8. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA mimics diacylglycerol (DAG) and activates protein kinase C (PKC). PKC phosphorylation can influence downstream signaling pathways that regulate translation initiation, indirectly enhancing the activity of Eukaryotic translation initiation factor 1A domain containing 8. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, stimulates adenylate cyclase activity leading to increased cAMP and PKA activation. This can enhance translation initiation mechanisms where Eukaryotic translation initiation factor 1A domain containing 8 is involved. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to an accumulation of cAMP which in turn activates PKA. Activated PKA can phosphorylate targets that are involved in the regulation of translation initiation, thereby enhancing the activity of Eukaryotic translation initiation factor 1A domain containing 8. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, resulting in increased cAMP levels and subsequent activation of PKA. This can enhance the activity of various factors involved in translation initiation, possibly including Eukaryotic translation initiation factor 1A domain containing 8. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can modulate signaling pathways linked to cellular proliferation and survival, possibly affecting translation initiation through phosphorylation events that could enhance the activity of Eukaryotic translation initiation factor 1A domain containing 8. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that directly activates PKA. PKA then phosphorylates serine and threonine residues on translation initiation factors, potentially enhancing the activity of Eukaryotic translation initiation factor 1A domain containing 8. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to the modulation of downstream targets of the PI3K/Akt pathway. This modulation could enhance translation initiation processes where Eukaryotic translation initiation factor 1A domain containing 8 is a participant. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the mTORC1 complex that negatively regulates protein synthesis. By inhibiting mTOR, rapamycin can indirectly enhance translation initiation by decreasing the inhibitory effects on processes that Eukaryotic translation initiation factor 1A domain containing 8 is involved in. | ||||||