EG665802 Activators
Pramel35 activators represent a distinct class of biochemical compounds that interact with cellular pathways to modulate the activity of the protein Pramel35. This class encompasses a diverse range of molecules, each with unique structures and mechanisms of action, yet all share the common functional outcome of enhancing the activity of Pramel35. These activators may work by various means, such as altering gene expression, modifying chromatin architecture, or affecting signal transduction pathways. Some activators might bind directly to DNA, modifying the transcriptional activity of genes encoding Pramel35 or its regulatory elements. Others may interact indirectly by influencing the cellular environment or the state of cofactors that are essential for Pramel35's activity. The biochemical effects of these molecules are complex and can involve multiple cellular components, including receptors, enzymes, and structural proteins, which all contribute to the modulation of Pramel35's functional state.
The complexity of the action of Pramel35 activators is further exemplified by their engagement with multiple cellular targets and pathways. For instance, compounds within this class might upregulate Pramel35 activity by affecting epigenetic markers, thereby altering the accessibility of chromatin and facilitating gene expression. Alternatively, they might activate or inhibit kinases or phosphatases that in turn modulate the phosphorylation state of proteins related to Pramel35 function. Some of these activators might also stabilize Pramel35 protein, enhance its interaction with other molecular partners, or prevent its degradation. The cellular consequences of activating Pramel35 are multifaceted, reflecting the interconnected nature of cellular signaling networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc acts as a cofactor for many proteins and can influence the androgen receptor's affinity and binding to DNA. This interaction can enhance the activity of proteins regulated by androgen receptors, including PRAME like 35. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $93.00 $258.00 $519.00 | ||
L-Lysine can influence histone methylation, thereby affecting chromatin structure and gene expression. This may enhance the expression and function of proteins like PRAME like 35 that are involved in chromatin regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs), which heterodimerize with retinoid X receptors (RXRs) and modulate gene expression. This can lead to upregulation of proteins involved in cell differentiation such as PRAME like 35. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), leading to stabilization and accumulation of β-catenin, which can enhance gene expression of Wnt target genes including those related to PRAME like 35 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit DNA methyltransferases, potentially leading to hypomethylation of DNA and activation of gene expression. Proteins like PRAME like 35, which are involved in chromatin modification, may have enhanced activity due to these changes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor leading to hyperacetylation of histones and an open chromatin state, which can enhance the expression of proteins involved in gene regulation, such as PRAME like 35. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is another HDAC inhibitor that leads to hyperacetylation of histones, promoting transcription of various genes, which can include those related to the functional activity of PRAME like 35. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound is a DNA methyltransferase inhibitor that can result in the demethylation of genes and enhance their expression. This may indirectly lead to the activation of PRAME like 35 by altering the expression of genes it interacts with. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which deacetylates proteins and affects their activity. Through modulation of protein function, SIRT1 activation can enhance the activity of proteins like PRAME like 35 involved in gene regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been found to inhibit NF-κB signaling, leading to changes in gene expression. By influencing this pathway, curcumin can enhance the activity of proteins such as PRAME like 35 that are regulated by NF-κB. | ||||||