EG637776 Activators
Zinc finger protein 977 activators encompass a cohort of chemicals that influence various cellular and biochemical pathways, which can enhance the transcription factor's activity. Forskolin and epinephrine, by increasing cAMP levels, activate PKA, which may phosphorylate and thus enhance the activity of zinc finger protein 977. Similarly, the inhibition of phosphodiesterases by IBMX leads to sustained cAMP levels, further potentiating the PKA-mediated phosphorylation of transcription factors. Retinoic acid and estrogen, through their receptor-mediated actions, modulate gene expression patterns, which may create a transcriptional environment that favors the activity of zinc finger protein 977. Likewise, dexamethasone, by influencing gene expression through glucocorticoid receptor interaction, can indirectly enhance the functional activity of this protein.
On the epigeneticfront, histone deacetylase inhibitors like Trichostatin A and Sodium Butyrate relax chromatin structure, which may facilitate zinc finger protein 977 binding to its target genes, enhancing its transcriptional activity. The inhibition of DNA methylation by 5-Aza-2'-deoxycytidine also promotes a transcriptionally permissive state that could augment the activity of zinc finger protein 977. Lithium chloride, by inhibiting GSK-3β, can impact the Wnt signaling pathway and potentially affect the functional activity of zinc finger protein 977 through downstream gene expression changes. The stabilization of client proteins by 17-AAG, if they are involved in the same pathways or directly interact with zinc finger protein 977, could result in enhanced activity of this transcription factor. Lastly, MG132, a proteasome inhibitor, prevents the degradation of proteins, which could lead to an increase in regulatory proteins that positively influence zinc finger protein 977's function, contributing to its enhanced action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, which activates G proteins and subsequently adenylyl cyclase, increasing cAMP. The cAMP acts as a second messenger to activate PKA, which, similar to forskolin, could enhance the functional activity of zinc finger protein 977 through phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX inhibits phosphodiesterases, which degrade cAMP. By preventing cAMP degradation, IBMX indirectly increases cAMP levels, thus potentially enhancing the activity of PKA and subsequently influencing the functional activity of zinc finger protein 977. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, a negative regulator of the Wnt signaling pathway. Although Wnt proteins themselves are excluded, lithium's effect on this pathway can alter gene expression patterns, which could indirectly enhance the functional activity of zinc finger protein 977 if it is involved in gene regulation downstream of Wnt signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression through its receptors which are transcription factors. As zinc finger protein 977 is a transcription factor, retinoic acid may enhance its activity by altering the transcriptional landscape and facilitating conditions that favor the functional activity of zinc finger protein 977. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen binds to estrogen receptors, leading to transcriptional regulation of genes. By altering the expression of genes that may interact with or affect the activity of zinc finger protein 977, estrogen can indirectly enhance its functional activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that binds to the glucocorticoid receptor, influencing gene expression. Through genomic actions, it may alter the expression of genes in a manner that enhances the functional activity of zinc finger protein 977. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which leads to a more relaxed chromatin structure and often enhances transcription. This change in chromatin structure may enhance the functional activity of zinc finger protein 977 by making its target genes more accessible for transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, similar to trichostatin A, potentially facilitating transcription factor access to DNA. This could enhance the activity of zinc finger protein 977 by increasing its access to target genes. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, leading to reduced DNA methylation and often resulting in gene activation. By demethylating genes that interact with or regulate zinc finger protein 977, it could enhance the functional activity of this protein. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an Hsp90 inhibitor which can lead to the stabilization and increased activity of various client proteins. If zinc finger protein 977 is a client protein or is regulated by client proteins of Hsp90, its activity could be enhanced. | ||||||