EG631584 Activators
Cation channel sperm associated auxiliary subunit epsilon 1 activators are characterized by their ability to modulate intracellular calcium levels or influence pathways that indirectly lead to the activation of the CATSPER channel. The diversity of these compounds allows for multiple points of intervention within cellular signaling cascades. For example, calcium ionophore A23187 and Ionomycin increase intracellular calcium directly, thereby activating cation channel sperm associated auxiliary subunit epsilon 1. Similarly, BAY K 8644, by acting as an L-type calcium channel agonist, indirectly heightens the activity of cation channel sperm associated auxiliary subunit epsilon 1 by promoting calcium influx essential for CATSPER channel function.
Moreover, compounds like OAG and PMA activate PKC, which then phosphorylates proteins that could be components of or regulators for cation channel sperm associated auxiliary subunit epsilon 1. Forskolin, acting through cAMP elevation, and subsequent PKA activation, represents another pathway through which cation channel sperm associated auxiliary subunit epsilon 1 activity can be enhanced. PKA is known to phosphorylate various proteins involved in sperm motility, which may include those associated with the CATSPER complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium concentration, directly activating cation channel sperm associated auxiliary subunit epsilon 1 by promoting the assembly and function of the CATSPER channel complex. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $119.00 $453.00 | 1 | |
Serves as a direct activator of protein kinase C (PKC), which can phosphorylate target proteins that regulate cation channel sperm associated auxiliary subunit epsilon 1, enhancing its activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Increases intracellular zinc concentrations, which may activate cation channel sperm associated auxiliary subunit epsilon 1, as zinc ions modulate various ion channels. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Modulates chloride channels, indirectly affecting cation channel sperm associated auxiliary subunit epsilon 1 activity by altering the electrochemical gradient. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Activates L-type calcium channels, increasing intracellular calcium essential for cation channel sperm associated auxiliary subunit epsilon 1 activation through the CATSPER channel. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Facilitates an increase in intracellular calcium concentration necessary for cation channel sperm associated auxiliary subunit epsilon 1 activation. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Activates the CATSPER channel, enhancing the activity of cation channel sperm associated auxiliary subunit epsilon 1. | ||||||