EG625464 Inhibitors
Ccdc121rt2, a retrogene encoding a coiled-coil domain, assumes a pivotal role in the intricate web of cellular signaling pathways. Functionally, it is intertwined with pathways such as MAPK, PI3K-Akt, JAK-STAT, and others, playing a crucial role in regulating cellular proliferation, survival, and stress responses. Inhibition of Ccdc121rt2 involves the modulation of these signaling pathways through various chemical inhibitors, each specifically targeting key nodes within the cascades that converge on Ccdc121rt2. The MAPK pathway, essential for cellular processes, is affected by MEK inhibitors like Trametinib and U0126, indirectly regulating Ccdc121rt2 expression by altering downstream events associated with gene transcription. Inhibition of the PI3K-Akt pathway by LY294002 and Wortmannin indirectly impacts Ccdc121rt2, influencing cellular responses linked to proliferation and survival. Additionally, JAK-STAT signaling is disrupted by JAK inhibitors like JAK inhibitor I, affecting Ccdc121rt2 expression by modulating gene transcription and cellular processes. Epigenetic modulators such as Trichostatin A and BIX 01294 influence histone modifications, indirectly affecting Ccdc121rt2 expression and its role in gene regulation.
Moreover, inhibitors targeting the p38 MAPK pathway (e.g., SB203580) and NF-κB pathway (e.g., BAY 11-7082) indirectly modulate Ccdc121rt2 expression by influencing downstream signaling events associated with stress responses and gene transcription. The mTOR pathway, regulated by inhibitors like AZD8055, also impacts Ccdc121rt2 by altering cellular processes linked to proliferation and survival. Overall, the comprehensive understanding of Ccdc121rt2 and its inhibition highlights the interconnectedness of cellular signaling networks, providing insights into potential strategies for finely tuned modulation of this retrogene's expression and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
MEK inhibitor targeting the MAPK pathway. Trametinib disrupts the MAPK pathway, indirectly impacting Ccdc121rt2 by altering downstream signaling events that regulate gene transcription and cellular processes associated with Ccdc121rt2 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3-kinase inhibitor influencing the PI3K-Akt signaling pathway. LY294002 indirectly regulates Ccdc121rt2 expression by blocking PI3-kinase activity, affecting downstream signaling cascades linked to cellular proliferation, survival, and gene transcription associated with Ccdc121rt2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor disrupting the p38 MAPK signaling pathway. SB203580 indirectly modulates Ccdc121rt2 expression by influencing the p38 MAPK pathway, altering downstream signaling events associated with cellular stress responses and gene transcription regulation. | ||||||
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $153.00 $332.00 | 59 | |
JAK inhibitor targeting the JAK-STAT signaling pathway. JAK inhibitor I disrupts the JAK-STAT pathway, indirectly impacting Ccdc121rt2 expression by altering downstream signaling events associated with gene transcription and cellular processes associated with Ccdc121rt2 function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
HDAC inhibitor affecting histone acetylation. Trichostatin A indirectly modulates Ccdc121rt2 expression by altering chromatin structure through histone acetylation modifications, influencing gene transcription and cellular processes associated with Ccdc121rt2. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
mTOR inhibitor influencing the mTOR signaling pathway. AZD8055 indirectly regulates Ccdc121rt2 expression by disrupting the mTOR pathway, impacting downstream signaling cascades associated with cellular proliferation, survival, and gene transcription linked to Ccdc121rt2 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor affecting the JNK signaling pathway. SP600125 indirectly modulates Ccdc121rt2 expression by inhibiting the JNK pathway, altering downstream signaling events linked to cellular stress responses and gene transcription regulation associated with Ccdc121rt2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3-kinase inhibitor disrupting the PI3K-Akt signaling pathway. Wortmannin indirectly influences Ccdc121rt2 expression by blocking PI3-kinase activity, affecting downstream signaling cascades associated with cellular proliferation, survival, and gene transcription linked to Ccdc121rt2 function. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
G9a histone methyltransferase inhibitor impacting histone methylation patterns. BIX 01294 indirectly regulates Ccdc121rt2 expression by modulating chromatin structure through histone methylation modifications, influencing gene transcription and cellular processes associated with Ccdc121rt2. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB inhibitor disrupting the NF-κB signaling pathway. BAY 11-7082 indirectly modulates Ccdc121rt2 expression by inhibiting the NF-κB pathway, altering downstream signaling events associated with gene transcription and cellular processes linked to Ccdc121rt2 function. | ||||||