EG545802 Activators
Hectd4, a HECT domain E3 ubiquitin protein ligase, is intricately involved in glucose homeostasis and glucose metabolic processes. Expressed in various tissues, including the extraembryonic component, nervous system, neural retina, reproductive system, and tongue, Hectd4 plays a crucial role in maintaining cellular energy balance and metabolic regulation. Activation of Hectd4 is influenced by a spectrum of chemical regulators targeting different cellular pathways. The AMP-activated protein kinase (AMPK) activator, A769662, directly stimulates Hectd4 by promoting its phosphorylation, enhancing ubiquitin ligase activity, and contributing to glucose homeostasis. Additionally, inhibitors such as MG132 stabilize Hectd4 protein levels by preventing its degradation, indirectly promoting glucose metabolic processes. Modulators of epigenetic regulation, including GSK343, impact Hectd4 expression by influencing histone methylation, further emphasizing the gene's role in glucose homeostasis.
Inhibition of glycolysis by 2-Deoxy-D-glucose, antagonism of PPARγ by GW9662, and modulation of MAPK/ERK signaling by SB203580 collectively influence Hectd4 expression, illustrating the intricate network of pathways involved in glucose regulation. These chemical interventions indirectly activate Hectd4, emphasizing its role as a central player in the maintenance of glucose homeostasis. The summarized activation mechanisms provide valuable insights into potential strategies for targeted modulation of Hectd4 in the context of glucose metabolism and cellular energy balance.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
AMP-activated protein kinase (AMPK) activator promoting Hectd4 activation. A769662 stimulates AMPK, leading to phosphorylation of Hectd4, enhancing its ubiquitin ligase activity and promoting glucose homeostasis. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor stabilizing Hectd4 protein levels. MG132 indirectly activates Hectd4 by preventing its degradation, resulting in increased ubiquitin ligase activity and contributing to glucose metabolic processes. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $148.00 $452.00 | 1 | |
Enhancer of zeste homolog 2 (EZH2) inhibitor influencing Hectd4 expression. GSK343 indirectly activates Hectd4 by modulating EZH2, leading to altered histone methylation and enhanced transcription of genes related to glucose homeostasis. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Glycolysis inhibitor impacting glucose metabolism. 2-Deoxy-D-glucose indirectly activates Hectd4 by altering cellular energy status, initiating signaling pathways that promote the ubiquitin ligase function and glucose homeostasis. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
Peroxisome proliferator-activated receptor gamma (PPARγ) antagonist impacting glucose homeostasis. GW9662 indirectly activates Hectd4 by inhibiting PPARγ, leading to enhanced ubiquitin ligase activity and modulation of glucose metabolism. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 mitogen-activated protein kinase (MAPK) inhibitor influencing Hectd4 expression. SB203580 indirectly activates Hectd4 by dampening p38 MAPK signaling, leading to altered transcriptional regulation and enhanced glucose homeostasis. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Mechanistic target of rapamycin (mTOR) inhibitor affecting Hectd4 activity. Torin 1 indirectly activates Hectd4 by inhibiting mTOR, leading to altered downstream signaling and enhanced ubiquitin ligase function in glucose metabolic processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Rho-associated protein kinase (ROCK) inhibitor influencing Hectd4 expression. Y27632 indirectly activates Hectd4 by modulating ROCK, leading to altered cytoskeletal dynamics and enhanced transcription of genes involved in glucose metabolic processes. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
ATP synthase inhibitor impacting cellular energy status. Oligomycin A indirectly activates Hectd4 by disrupting ATP synthesis, initiating signaling pathways that enhance the ubiquitin ligase function and contribute to glucose homeostasis. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MAPK/ERK kinase (MEK) inhibitor influencing Hectd4 expression. PD98059 indirectly activates Hectd4 by blocking MEK, leading to altered MAPK/ERK signaling and enhanced transcription of genes related to glucose homeostasis. | ||||||