EG333452 Activators
H2al1o, a member of the H2A histone family, functions as a crucial player in cellular processes, particularly DNA binding activity and heterochromatin assembly. Its predicted role suggests an integral involvement in regulating chromatin structure and gene expression. The activation of H2al1o is intricately linked to the modulation of chromatin dynamics, where specific chemicals play pivotal roles in influencing its DNA binding activity and contributing to heterochromatin assembly.
The activation of H2al1o can be achieved through various chemicals that influence histone modifications and chromatin structure. Trichostatin A and Sodium Butyrate, for instance, up-regulate H2al1o by inhibiting HDACs, leading to increased histone acetylation and enhanced DNA binding activity, contributing to the assembly of heterochromatin. 5-Azacytidine and Zebularine indirectly activate H2al1o by inhibiting DNA methyltransferases, reducing DNA methylation, and facilitating accessible chromatin for DNA binding and assembly. Etoposide and Camptothecin induce DNA damage, increasing H2al1o recruitment to damaged sites and enhancing DNA binding activity, thereby contributing to heterochromatin assembly. In summary, the dynamic activation of H2al1o involves a complex interplay of chemicals that influence chromatin modifications and structure, ultimately regulating DNA binding activity and contributing to the assembly of heterochromatin. Understanding these mechanisms provides valuable insights into the intricate regulation of chromatin dynamics and the functional role of H2al1o in maintaining genomic integrity and stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A up-regulates H2al1o by inhibiting HDACs, leading to increased histone acetylation and enhanced DNA binding activity, promoting heterochromatin assembly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine indirectly activates H2al1o by inhibiting DNA methyltransferases, reducing DNA methylation, and promoting accessible chromatin for binding and assembly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate stimulates H2al1o by inhibiting HDACs, promoting histone acetylation, and enhancing DNA binding activity, contributing to heterochromatin assembly. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide induces DNA damage, leading to increased H2al1o recruitment to damaged sites, enhancing DNA binding activity and contributing to heterochromatin assembly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin up-regulates H2al1o by inhibiting HDACs, increasing histone acetylation, and promoting DNA binding activity, contributing to heterochromatin assembly. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine indirectly activates H2al1o by inhibiting DNA methyltransferases, reducing DNA methylation, and facilitating accessible chromatin for DNA binding and assembly. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA stimulates H2al1o by inhibiting HDACs, enhancing histone acetylation, and promoting DNA binding activity, contributing to heterochromatin assembly. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin induces DNA damage, leading to increased H2al1o recruitment to damaged sites, enhancing DNA binding activity and contributing to heterochromatin assembly. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid up-regulates H2al1o by inhibiting HDACs, increasing histone acetylation, and promoting DNA binding activity, contributing to heterochromatin assembly. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid stimulates H2al1o by inhibiting HDACs, enhancing histone acetylation, and promoting DNA binding activity, contributing to heterochromatin assembly. | ||||||