EG240038 Activators
Zfp994, a zinc finger protein, emerges as a key player in the intricate landscape of transcriptional regulation by RNA polymerase II. Predicted to possess DNA-binding transcription factor activity with specificity towards RNA polymerase II cis-regulatory regions, Zfp994 is predominantly active within the nucleus. The function of this protein revolves around its ability to modulate gene expression by interacting with specific DNA sequences, facilitating the orchestration of intricate cellular processes. At the core of Zfp994's functionality is its role as a regulator of transcription by RNA polymerase II. The protein, equipped with zinc finger motifs, engages in sequence-specific DNA binding, enabling it to interact with target cis-regulatory regions. Within the nucleus, Zfp994 facilitates the activation or repression of gene expression, contributing to the finely tuned orchestration of cellular processes. This function positions Zfp994 as a critical component in the intricate machinery governing the transcriptional landscape, emphasizing its role in the dynamic control of RNA polymerase II-mediated transcription.
The activation of Zfp994 involves a complex interplay of cellular mechanisms that modulate its DNA-binding transcription factor activity. While the detailed description of specific chemicals is omitted here, it's essential to underscore that the general mechanisms of activation encompass modulation of histone acetylation, methylation patterns, bromodomain activity, DNA methylation, and protein degradation. These processes collectively contribute to the up-regulation and stimulation of Zfp994, enhancing its ability to bind to specific DNA sequences and regulate transcription. The intricacy of these activation pathways reflects the sophistication of the cellular machinery involved in precisely controlling gene expression through Zfp994. Understanding these general mechanisms sheds light on the dynamic regulatory network in which Zfp994 operates, providing insights into potential strategies for manipulating transcriptional processes and influencing cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, an HDAC inhibitor, up-regulates Zfp994 by modulating histone acetylation. HDAC inhibition enhances RNA polymerase II-specific DNA binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 activity in the nucleus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA demethylating agent, indirectly activates Zfp994 by influencing DNA methylation patterns. Demethylation enhances RNA polymerase II cis-regulatory region binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 function in the nucleus. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1, a BET bromodomain inhibitor, up-regulates Zfp994 by modulating bromodomain activity. BET inhibition enhances RNA polymerase II-specific DNA binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 activity in the nucleus. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, indirectly activates Zfp994 by influencing DNA topology. Topoisomerase I inhibition enhances RNA polymerase II cis-regulatory region binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 function in the nucleus. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Sodium Valproate, an HDAC inhibitor, up-regulates Zfp994 by modulating histone acetylation. HDAC inhibition enhances RNA polymerase II-specific DNA binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 activity in the nucleus. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX-01294, a G9a histone methyltransferase inhibitor, indirectly activates Zfp994 by modulating histone methylation. G9a inhibition enhances RNA polymerase II cis-regulatory region binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 function in the nucleus. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646, a p300/CBP histone acetyltransferase inhibitor, up-regulates Zfp994 by modulating histone acetylation. p300/CBP inhibition enhances RNA polymerase II-specific DNA binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 activity in the nucleus. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol, a CDK inhibitor, indirectly activates Zfp994 by influencing cell cycle dynamics. CDK inhibition enhances RNA polymerase II cis-regulatory region binding, promoting transcriptional activity. This chemical triggers a cascade leading to increased Zfp994 function in the nucleus. | ||||||