EG238829 Activators
Cldn34b3, a member of the claudin family, emerges as a pivotal player in cellular processes, specifically contributing to bicellular tight junction assembly and cell adhesion. This gene is predicted to be actively involved in the formation of tight junctions between adjacent cells, reinforcing cellular barriers and maintaining tissue integrity. Its presence at the plasma membrane further underscores its role in facilitating cell adhesion, a fundamental aspect of cellular interactions and tissue architecture. Sharing orthology with human CLDN34, Cldn34b3 exhibits conserved functions, suggesting its importance across species in regulating tight junction dynamics.
The function of Cldn34b3 revolves around its participation in bicellular tight junction assembly, a process critical for cellular barriers and paracellular permeability control. Tight junctions act as molecular seals between adjacent cells, influencing the passage of ions, molecules, and even pathogens. Cldn34b3's engagement in these processes emphasizes its significance in cellular homeostasis and tissue function. Understanding the general mechanisms of Cldn34b3 activation sheds light on the intricate signaling pathways involved. These pathways serve as regulatory networks that modulate the expression and function of Cldn34b3, impacting tight junction assembly and cell adhesion. The activation of Cldn34b3 is orchestrated by a diverse set of intracellular signaling cascades, influenced by various chemicals. These chemicals, though not explicitly named, play roles in key cellular processes such as SIRT1 modulation, ER stress induction, cAMP elevation, Wnt signaling, and actin cytoskeleton dynamics. The interplay between these pathways results in the up-regulation, stimulation, enhancement, or triggering of Cldn34b3, ultimately contributing to the assembly of tight junctions and promotion of cell adhesion. The complexity of these mechanisms highlights the sophisticated regulatory networks controlling Cldn34b3 activation, providing insights into potential avenues for manipulating cellular barrier function and tissue integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, activates Cldn34b3 by modulating the SIRT1 pathway. SIRT1 deacetylation enhances tight junction assembly, promoting cell adhesion. The activation occurs via a direct interaction, impacting the plasma membrane and tight junction dynamics. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin, a SERCA inhibitor, indirectly up-regulates Cldn34b3 by inducing ER stress. ER stress activates UPR, promoting tight junction assembly. This chemical triggers a cascade leading to increased protein expression at the plasma membrane, positively impacting cell adhesion. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride, a GSK-3 inhibitor, up-regulates Cldn34b3 by modulating Wnt signaling. Inhibition of GSK-3 activates the Wnt pathway, promoting tight junction assembly. This chemical triggers a cascade leading to enhanced protein expression at the plasma membrane, positively affecting cell adhesion. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a ROCK inhibitor, indirectly activates Cldn34b3 by influencing actin cytoskeleton dynamics. ROCK inhibition enhances tight junction formation, impacting cell adhesion. This chemical triggers a cascade leading to increased protein expression at the plasma membrane, positively modulating tight junctions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates Cldn34b3 by modulating the RAR/RXR pathway. Activation of RAR/RXR enhances tight junction assembly, directly impacting bicellular tight junctions. The activation occurs through intracellular signaling pathways, influencing plasma membrane dynamics and promoting cell adhesion. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, a histone deacetylase inhibitor, indirectly up-regulates Cldn34b3. HDAC inhibition enhances tight junction formation, positively impacting cell adhesion. This chemical triggers a cascade leading to increased protein expression at the plasma membrane, influencing tight junction dynamics. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187, a calcium ionophore, activates Cldn34b3 by influencing intracellular calcium levels. Increased calcium levels enhance tight junction assembly, directly impacting bicellular tight junctions. The activation occurs through intracellular signaling pathways, influencing plasma membrane dynamics and promoting cell adhesion. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Cldn34b3 by modulating PKC signaling. PKC activation enhances tight junction formation, directly impacting bicellular tight junctions. This chemical triggers a cascade leading to increased protein expression at the plasma membrane, positively influencing cell adhesion. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine up-regulates Cldn34b3 by modulating the mTOR pathway. Activation of mTOR enhances tight junction assembly, directly impacting bicellular tight junctions. This chemical triggers a cascade leading to increased protein expression at the plasma membrane, positively influencing cell adhesion. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates Cldn34b3 by modulating the p38 MAPK pathway. Inhibition of p38 MAPK enhances tight junction formation, positively impacting cell adhesion. This chemical triggers a cascade leading to increased protein expression at the plasma membrane, influencing tight junction dynamics. | ||||||