EG236749 Activators
Tesl1, a zinc ion-binding protein predicted to be located in the cytosol, focal adhesion, and plasma membrane, plays a crucial role in negatively regulating cell population proliferation. As a member of the LIM domain protein family, Tesl1 is implicated in maintaining cellular homeostasis and modulating cellular responses to external signals. Activation of Tesl1 involves a diverse array of chemicals that directly or indirectly impact its function. Zinc ion enhancers like ZINC13408198, Zinc Acetate, and Clioquinol directly activate Tesl1 by promoting zinc ion binding, highlighting the significance of metal ion homeostasis in controlling cellular proliferation. Additionally, AMPK activators such as A769662, Metformin, and Berberine indirectly activate Tesl1 by stimulating AMPK activity, emphasizing the role of energy sensing pathways in modulating cellular proliferation dynamics.
Inhibition of p38 MAPK by SB203580 and SB202190, suppression of the MAPK/ERK pathway by PD98059, and inhibition of the PI3K/Akt pathway by Wortmannin indirectly activate Tesl1 by negatively regulating cell proliferation, illustrating the intricate connection between pathway modulation and Tesl1 activation. Furthermore, zinc ion enhancers like Quercetin and Zinc Sulfate contribute to Tesl1 activation, underlining the crucial role of metal ions in fine-tuning its regulatory functions. In summary, Tesl1 emerges as a key player in cellular proliferation control, with its activation intricately linked to zinc ion homeostasis and energy sensing pathways. The interplay between these diverse chemicals and Tesl1 provides insights into the complex regulatory network governing cell population dynamics, shedding light on potential strategies for modulating cellular proliferation in various physiological and pathological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
ZINC13408198, a zinc ion enhancer, directly activates Tesl1 by promoting zinc ion binding. This facilitates Tesl1's role in negative regulation of cell proliferation. The specific interaction with zinc ions underscores the crucial role of metal ion homeostasis in modulating Tesl1 activity and controlling cellular proliferation in the cytosol and plasma membrane. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates Tesl1 by suppressing the p38 MAPK pathway. Inhibition of p38 MAPK negatively regulates cell proliferation, indirectly enhancing Tesl1 function. This highlights the intricate connection between SB203580-mediated pathway modulation and the subsequent activation of Tesl1 in focal adhesion and plasma membrane locations. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662, an AMPK activator, indirectly activates Tesl1 by stimulating AMPK activity. Activation of AMPK negatively regulates cell proliferation, indirectly enhancing Tesl1 function. The interplay between A769662-mediated AMPK activation and Tesl1 underscores the significance of energy sensing pathways in modulating cellular proliferation dynamics in focal adhesion and plasma membrane locations. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor, indirectly activates Tesl1 by suppressing the MAPK/ERK pathway. Inhibition of the MAPK/ERK pathway negatively regulates cell proliferation, indirectly enhancing Tesl1 function. This emphasizes the intricate connection between PD98059-mediated pathway modulation and the subsequent activation of Tesl1 in focal adhesion and plasma membrane locations. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride, an AMPK activator, indirectly activates Tesl1 by stimulating AMPK activity. Activation of AMPK negatively regulates cell proliferation, indirectly enhancing Tesl1 function. The interplay between Metformin-mediated AMPK activation and Tesl1 underscores the significance of energy sensing pathways in modulating cellular proliferation dynamics in focal adhesion and plasma membrane locations. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Clioquinol, a zinc ion enhancer, directly activates Tesl1 by promoting zinc ion binding. This facilitates Tesl1's role in negative regulation of cell proliferation. The specific interaction with zinc ions underscores the crucial role of metal ion homeostasis in modulating Tesl1 activity and controlling cellular proliferation in the cytosol and plasma membrane. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an AMPK activator, indirectly activates Tesl1 by stimulating AMPK activity. Activation of AMPK negatively regulates cell proliferation, indirectly enhancing Tesl1 function. The interplay between Berberine-mediated AMPK activation and Tesl1 underscores the significance of energy sensing pathways in modulating cellular proliferation dynamics in focal adhesion and plasma membrane locations. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a zinc ion enhancer, directly activates Tesl1 by promoting zinc ion binding. This facilitates Tesl1's role in negative regulation of cell proliferation. The specific interaction with zinc ions underscores the crucial role of metal ion homeostasis in modulating Tesl1 activity and controlling cellular proliferation in the cytosol and plasma membrane. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, indirectly activates Tesl1 by suppressing the PI3K/Akt pathway. Inhibition of the PI3K/Akt pathway negatively regulates cell proliferation, indirectly enhancing Tesl1 function. This emphasizes the intricate connection between Wortmannin-mediated pathway modulation and the subsequent activation of Tesl1 in focal adhesion and plasma membrane locations. | ||||||