EG236749 Inhibitors
Tesl1, predicted to enable zinc ion binding activity and play a role in the negative regulation of cell population proliferation, emerges as a key regulator in cellular processes. The direct and indirect inhibitors presented in the table highlight diverse strategies for modulating Tesl1. Direct inhibitors like TPEN specifically target Tesl1's predicted zinc ion binding activity, potentially disrupting its functional role and leading to inhibition of cell proliferation.
Indirect inhibitors, such as PD 0332991 and Wortmannin, modulate pathways related to Tesl1, impacting its negative regulation of cell population proliferation. Sorafenib and Rapamycin influence pathways like Raf/MEK/ERK and mTORC1, respectively, showcasing the intricate regulatory network that Tesl1 is a part of. Inhibition of Tesl1 involves interference at multiple levels, including cellular energy balance, cytoskeletal dynamics, and growth factor signaling. These inhibitors provide a comprehensive approach to understanding Tesl1's function and present potential avenues for further investigation into its precise role in cellular processes.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Zinc chelator inhibiting zinc ion binding. Directly targets Tesl1's predicted zinc ion binding activity, potentially disrupting its functional role and leading to inhibition of negative regulation of cell proliferation. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
CDK4/6 inhibitor affecting cell cycle progression. Indirectly influences Tesl1 by modulating cell proliferation pathways, potentially impacting its role in the negative regulation of cell population proliferation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor affecting the PI3K-Akt pathway. Indirectly modulates pathways related to Tesl1, potentially interfering with its negative regulation of cell population proliferation by influencing downstream signaling. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $179.00 $700.00 | 9 | |
AMPK inhibitor affecting cellular energy balance. Indirectly influences Tesl1 by modulating energy-related pathways, potentially impacting its role in negative regulation of cell population proliferation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor influencing mTORC1 signaling. Indirectly modulates pathways connected to Tesl1, potentially affecting its negative regulation of cell population proliferation through mTORC1. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Raf/MEK/ERK pathway inhibitor. Indirectly influences Tesl1 through the modulation of the Raf/MEK/ERK pathway, potentially impacting its role in negative regulation of cell population proliferation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor affecting the PI3K-Akt pathway. Modulates pathways related to Tesl1, potentially interfering with its negative regulation of cell population proliferation by influencing downstream signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor affecting cytoskeletal dynamics. Indirectly influences Tesl1 by modulating cytoskeletal organization, potentially impacting its cellular localization and function in negative regulation of cell proliferation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β receptor inhibitor affecting the TGF-β signaling pathway. Modulates pathways related to Tesl1 through TGF-β inhibition, potentially influencing its negative regulation of cell population proliferation. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
AMPK inhibitor affecting cellular energy balance. Indirectly influences Tesl1 by modulating energy-related pathways, potentially impacting its role in negative regulation of cell population proliferation. | ||||||