EG210853 Activators
Zfp947, a zinc finger protein predicted to enable DNA-binding transcription factor activity and regulate transcription by RNA polymerase II, operates within the nucleus, indicating its critical role in gene expression modulation. The protein is anticipated to play a pivotal role in orchestrating transcriptional events by interacting with specific DNA sequences and RNA polymerase II cis-regulatory regions. To activate Zfp947, various chemicals can be considered, each influencing specific pathways and cellular processes. Histone deacetylase inhibitors like Trichostatin A, Vorinostat, Sodium Valproate, and Scriptaid up-regulate Zfp947 by fostering histone acetylation. This epigenetic modification enhances the protein's DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. DNA methyltransferase inhibitors such as 5-Azacytidine and 3-Deazaneplanocin A indirectly activate Zfp947 by demethylating DNA, amplifying RNA polymerase II cis-regulatory region sequence-specific DNA binding activity.
Curcumin activates Zfp947 by influencing the NF-κB signaling pathway, enhancing DNA-binding transcription factor activity and promoting RNA polymerase II-specific binding. Etoposide influences topoisomerase II, contributing to the up-regulation of transcriptional regulation processes. Sodium butyrate and Sodium valproate activate Zfp947 by promoting histone acetylation. ATRA activates Zfp947 by influencing retinoic acid receptors, enhancing DNA-binding transcription factor activity. Betulinic acid activates Zfp947 by modulating signaling pathways, contributing to the up-regulation of transcriptional regulation processes. RG108, a DNA methyltransferase inhibitor, indirectly activates Zfp947 by demethylating DNA. In essence, the activation of Zfp947 involves a sophisticated interplay of various chemicals that modulate specific pathways and cellular processes, ultimately contributing to its functions in DNA-binding transcription factor activity and RNA polymerase II-mediated transcriptional regulation. These chemicals, by directly or indirectly influencing Zfp947, provide a comprehensive understanding of potential activators for this zinc finger protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, up-regulates Zfp947 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, facilitating transcriptional regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, indirectly activates Zfp947 by demethylating DNA. This epigenetic modification promotes transcription factor binding and amplifies RNA polymerase II cis-regulatory region sequence-specific DNA binding activity, enhancing transcriptional regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates Zfp947 by influencing the NF-κB signaling pathway. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid, a histone deacetylase inhibitor, up-regulates Zfp947 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, an HDAC inhibitor, activates Zfp947 by promoting histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity, stimulating RNA polymerase II-specific binding and facilitating the regulation of transcription. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide activates Zfp947 by influencing the topoisomerase II enzyme. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid sodium salt, a histone deacetylase inhibitor, up-regulates Zfp947 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA activates Zfp947 by influencing retinoic acid receptors. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid, a histone deacetylase inhibitor, up-regulates Zfp947 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid activates Zfp947 by modulating signaling pathways. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||