EG210583 Activators
Gm4767, a predicted gene with the potential to exert DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding, operates within the nucleus, playing a key role in the regulation of transcription processes. Predicted to be involved in the modulation of RNA polymerase II-mediated transcription, Gm4767 is anticipated to enable the binding of transcription factors to specific DNA sequences, influencing the intricate orchestration of gene expression. Its activity in the nucleus suggests a pivotal role in the control and coordination of cellular responses, particularly in the fine-tuning of gene expression patterns.
The general mechanisms of Gm4767 activation involve the modulation of epigenetic factors and signaling pathways. Epigenetic regulation, notably through histone deacetylase inhibitors and DNA methyltransferase inhibitors, emerges as a crucial aspect of Gm4767 activation. These chemicals act by fostering histone acetylation or demethylating DNA, respectively, ultimately enhancing the protein's DNA-binding transcription factor activity and its interaction with RNA polymerase II cis-regulatory regions. Additionally, the influence of specific signaling pathways, such as NF-κB, is highlighted as a key mechanism of Gm4767 activation. By responding to external stimuli or intracellular signals, these pathways contribute to the up-regulation of Gm4767, further emphasizing its role in orchestrating transcriptional events. In essence, Gm4767 emerges as a pivotal player in the intricate machinery of transcriptional regulation, operating within the nucleus to modulate RNA polymerase II-mediated transcription. Its activation is intricately tied to epigenetic modifications and signaling pathway responses, reflecting a sophisticated interplay of molecular events that fine-tune gene expression. Understanding these activation mechanisms sheds light on the potential regulatory functions of Gm4767 in the cellular context, providing a foundation for further exploration of its role in the broader landscape of transcriptional control.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, up-regulates Gm4767 by promoting histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, facilitating transcriptional regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, indirectly activates Gm4767 by demethylating DNA. This epigenetic modification promotes transcription factor binding and amplifies RNA polymerase II cis-regulatory region sequence-specific DNA binding activity, enhancing transcriptional regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates Gm4767 by influencing the NF-κB signaling pathway. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid, a histone deacetylase inhibitor, up-regulates Gm4767 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, an HDAC inhibitor, activates Gm4767 by promoting histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity, stimulating RNA polymerase II-specific binding and facilitating the regulation of transcription. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide activates Gm4767 by influencing the topoisomerase II enzyme. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Sodium valproate, a histone deacetylase inhibitor, up-regulates Gm4767 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
ATRA activates Gm4767 by influencing retinoic acid receptors. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
Scriptaid, a histone deacetylase inhibitor, up-regulates Gm4767 by fostering histone acetylation. This epigenetic modification enhances DNA-binding transcription factor activity and stimulates RNA polymerase II-specific binding, promoting transcriptional regulation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid activates Gm4767 by modulating signaling pathways. Its impact enhances DNA-binding transcription factor activity and promotes RNA polymerase II-specific binding, contributing to the up-regulation of transcriptional regulation processes. | ||||||