EEPD1 Activators
EEPD1 activators consist of a series of chemical compounds that enhance the functional activity of EEPD1 through their involvement in various biochemical processes essential for DNA repair. Zinc acts as a crucial cofactor for proteins involved in DNA damage response and repair, such as EEPD1, which plays a pivotal role in end resection during homologous recombination. EEPD1's activity is further supported by Resveratrol, which activates the SIRT1 pathway to promote DNA repair mechanisms, and NAD+ and NMN, which enhance the function of sirtuins and PARPs, thereby indirectly contributing to the optimal environment for EEPD1's DNA repair activities. Additionally, substrates like NADPH and glucose, through their role in maintaining the cellular redox state and providing reducing power, ensure the integrity of the DNA repair process where EEPD1 is critical.
Manganese (II) chloride and ATP are also key, with manganese bolstering antioxidant defenses and ATP supplying the energy required for the intricate DNA repair tasks in which EEPD1 is engaged. Acetyl-CoA and S-adenosylmethionine (SAM) further modulate EEPD1's function by serving as donors for acetylation and methylation reactions, respectively, these post-translational modifications can profoundly influence DNA repair proteins' activity and genomic stability. Ascorbic acid supports EEPD1 by protecting the genome from oxidative stress, thereby indirectly preserving the functionality of DNA repair proteins. Lastly, α-Ketoglutarate facilitates DNA and histone demethylation processes, which are critical for the regulation of gene expression and DNA repair, thereby supporting the cellular roles of EEPD1 in maintaining genomic integrity. Together, these compounds, by targeting different aspects of cellular metabolism and genomic maintenance, synergistically enhance the activity of EEPD1, ensuring efficient and accurate DNA repair pathways are sustained.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor in numerous enzymes, including those involved in DNA damage and repair. EEPD1 is implicated in end resection in DNA repair, and adequate zinc levels are crucial for the proper functioning of such proteins that partake in DNA repair mechanisms. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates the SIRT1 pathway, which is involved in DNA repair and genomic stability. SIRT1 activation can enhance the activity of EEPD1 as it is involved in DNA end resection, a critical step in homologous recombination repair. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is essential for the function of many enzymes, including those involved in the response to oxidative stress. EEPD1, being part of the DNA repair process, could be indirectly activated by manganese through the enhancement of antioxidant defenses which help maintain DNA integrity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a substrate for sirtuins and PARPs which are involved in DNA repair. Increased NAD+ levels can enhance the activity of DNA repair proteins, indirectly supporting EEPD1's role in DNA end resection during repair processes. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN boosts NAD+ levels in cells, indirectly enhancing the activity of sirtuins and PARPs, and thus potentially supporting the DNA repair function of EEPD1 by providing a more optimal environment for DNA repair processes. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH is crucial for maintaining cellular redox state and the function of glutathione systems. By protecting cells from oxidative stress, NADPH indirectly supports the integrity of DNA repair processes in which EEPD1 is involved. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose metabolism through the pentose phosphate pathway produces NADPH, indirectly supporting the DNA repair functions by providing reducing power to counteract oxidative stress which can otherwise impede the function of DNA repair proteins like EEPD1. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP is essential for numerous cellular functions, including DNA repair processes. It provides the necessary energy for the activity of DNA repair proteins, potentially enhancing the function of EEPD1 during end resection in homologous recombination. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Ademetionine serves as a methyl donor for DNA methylation, which is crucial for the regulation of gene expression and DNA repair. Adequate levels of SAM could support the DNA repair function of EEPD1 by maintaining proper genomic methylation patterns. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is an antioxidant that helps protect cells from oxidative damage, which can lead to DNA breaks. By maintaining genomic integrity, it indirectly supports the DNA repair activity of EEPD1. | ||||||