Date published: 2025-10-15

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eEF2K Inhibitors

eEF2K, an abbreviation for eukaryotic elongation factor-2 kinase, plays an instrumental role in the process of protein synthesis within cells. This kinase is responsible for phosphorylating its substrate, eEF2 (eukaryotic elongation factor-2), which in turn influences the elongation step in protein synthesis. The eEF2K enzyme, by modulating the activity of eEF2, thus exerts control over the rate of peptide chain elongation, allowing cells to regulate protein synthesis in response to various signals and environmental cues. Inhibitors targeting eEF2K have emerged as a captivating subject of study within the domain of biochemistry and cell biology. These molecules have the capability to inhibit the enzymatic function of eEF2K, thereby impeding its effect on eEF2 and consequently influencing the overall process of protein synthesis. The development of such inhibitors has been guided by the structural nuances of eEF2K, utilizing both high-throughput screening and other strategies. Investigations into the intricate molecular mechanisms of these inhibitors have elucidated their modes of action, binding sites, and their effects on cellular pathways. This understanding has shed light on the broader roles eEF2K plays in various cellular processes beyond just protein synthesis, and it underscores the importance of deciphering the interplay between this kinase and its molecular partners within the cell.

Items 1 to 10 of 15 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rottlerin

82-08-6sc-3550
sc-3550B
sc-3550A
sc-3550C
sc-3550D
sc-3550E
10 mg
25 mg
50 mg
1 g
5 g
20 g
$82.00
$163.00
$296.00
$2050.00
$5110.00
$16330.00
51
(2)

Rottlerin (CAS 82-08-6) is a polyphenolic compound originally isolated from the Kamala tree (Mallotus philippensis). It has been identified as an inhibitor of eEF2K (eukaryotic elongation factor-2 kinase). eEF2K is involved in protein synthesis, and Rottlerin's inhibition of this kinase has been explored in various cellular and molecular studies. The precise mechanism of Rottlerin's action and specificity towards eEF2K remains a subject of research.

NH125

278603-08-0sc-203037
5 mg
$187.00
1
(1)

NH125 (CAS 278603-08-0) is a chemical compound that acts as an inhibitor of eEF2K (eukaryotic elongation factor-2 kinase). eEF2K plays a role in protein synthesis regulation, and the inhibitory effects of NH125 on this kinase have been studied in various cellular and molecular contexts. NH125's specific interactions with eEF2K and its downstream effects are areas of active investigation in the scientific community.

TX-1123

157397-06-3sc-296675
10 mg
$185.00
(0)

TX-1123, functioning as an eEF2K, exhibits intriguing characteristics as an acid halide, particularly in its capacity to modulate protein synthesis pathways. Its unique structure allows for specific interactions with key amino acid residues, influencing phosphorylation states. The compound's reactivity is enhanced by its ability to form transient intermediates, which can lead to diverse reaction kinetics. Additionally, TX-1123's hydrophobic regions promote membrane interactions, impacting cellular signaling dynamics.

A 484954

142557-61-7sc-479613
10 mg
$175.00
(0)

A 484954 is a selective eEF2K inhibitor. It inhibits the kinase activity of eEF2K, which might decrease its expression over time.

TX-1918

503473-32-3sc-296676
sc-296676A
sc-296676B
10 mg
50 mg
250 mg
$222.00
$714.00
$1301.00
1
(1)

TX-1918 is a chemical compound that acts as an eEF2K inhibitor. It has been studied for its potential to modulate protein synthesis and cell growth by targeting the eEF2K enzyme. Research has shown that TX-1918 can effectively inhibit eEF2K activity, leading to potential implications for understanding the molecular mechanisms involved in protein synthesis regulation. Its mechanism of action as an eEF2K inhibitor has garnered interest in scientific research for its potential applications in studying cellular processes and signaling pathways.

Monensin A

17090-79-8sc-362032
sc-362032A
5 mg
25 mg
$152.00
$515.00
(1)

Monensin A is known to inhibit protein synthesis. This can indirectly affect the expression of eEF2K in cells.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin inhibits mTOR, which indirectly regulates eEF2K. By targeting mTOR, eEF2K activity and expression may be influenced.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$60.00
$270.00
$350.00
48
(2)

AICAR affects the AMPK pathway, which has a regulatory role over eEF2K. This can potentially lead to decreased eEF2K expression.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin inhibits PI3K, a pathway that has an indirect effect on eEF2K. This might influence eEF2K activity and expression.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$92.00
$260.00
42
(2)

Roscovitine is a CDK inhibitor that can affect various cell cycle proteins, potentially influencing eEF2K expression indirectly.