Molecular structure of NH125, CAS Number: 278603-08-0
NH125 (CAS 278603-08-0)
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Alternate Names:
eEF-2 Kinase Inhibitor; 1-Benzyl-3-cetyl-2-methylimidazolium iodide
Application:
NH125 is an inhibitor of multiple kinases
CAS Number:
278603-08-0
Purity:
≥95%
Molecular Weight:
524.56
Molecular Formula:
C27H45N2•I
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NH125 is a cell-permeable imidazolium compound that has been used to study anticancer therapies. eEF2K is an ubiquitous protein kinase that phosphorylates and inactivates eEF2, and thus can modulate the rate of polypeptide chain elongation during translation. NH125 may act to inhibit cancer cell growth through inhibition of eukaryotic elongation eEF2K (factor-2 kinase). NH125 induces eEF2 phosphorylation inhibition of cancer cell growth is correlated with induction of p-eEF2. NH125 is an inhibitor of CaMK.
NH125 (CAS 278603-08-0) References
- Identification and characterization of a potent antibacterial agent, NH125 against drug-resistant bacteria. | Yamamoto, K., et al. 2000. Biosci Biotechnol Biochem. 64: 919-23. PMID: 10830522
- Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. | Arora, S., et al. 2003. Cancer Res. 63: 6894-9. PMID: 14583488
- P-glycoprotein mediates resistance to histidine kinase inhibitors. | Arora, S., et al. 2004. Mol Pharmacol. 66: 460-7. PMID: 15322237
- 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. | Chen, Z., et al. 2011. J Biol Chem. 286: 43951-43958. PMID: 22020937
- Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. | Devkota, AK., et al. 2012. Biochemistry. 51: 2100-12. PMID: 22352903
- Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma. | Zhao, YY., et al. 2018. Drug Des Devel Ther. 12: 2655-2663. PMID: 30214154
Inhibitor of:
c-Fgr, CaMK, Ear4, eEF2K, MRCL3, PLEKHM2, and TBK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NH125, 5 mg | sc-203037 | 5 mg | $191.00 |