Date published: 2026-5-30

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EBV Ea-R p85 Inhibitors

EBV Ea-R p85 refers to a protein associated with the Epstein-Barr virus (EBV), a herpesvirus that can cause infectious mononucleosis and is linked to various types of cancer, including Burkitt's lymphoma, Hodgkin's lymphoma, and nasopharyngeal carcinoma. The EBV early antigen complex, which includes Ea-R p85, plays a crucial role in the virus's life cycle, particularly in the reactivation from latency and the early phase of viral replication. The regulation of this protein and its associated functions is critical for the EBV's ability to persist in infected cells and contribute to oncogenesis. The general mechanisms of inhibition for EBV Ea-R p85 involve targeting the signaling pathways and cellular processes that support the virus's life cycle, including latency, reactivation, and replication. Inhibitors may act indirectly by affecting cellular signaling pathways such as NF-κB, PI3K/AKT, and mTOR, which are crucial for the survival, proliferation, and transformation of EBV-infected cells. By disrupting these pathways, the inhibitors can create an unfavorable environment for EBV persistence, potentially leading to reduced expression of viral proteins like Ea-R p85. This strategy relies on understanding the complex interactions between the virus and host cell signaling mechanisms, aiming to target the underlying processes that facilitate EBV infection and its associated pathologies without directly targeting the virus itself.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

Valproic acid, a histone deacetylase inhibitor, can alter chromatin structure and gene expression, potentially affecting EBV latency and reactivation. By modifying the epigenetic landscape, it may indirectly suppress EBV Ea-R p85 expression.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$62.00
$85.00
$356.00
155
(1)

Bay 11-7082 inhibits NF-κB activation, a pathway critical for EBV-mediated B-cell transformation and viral gene expression. Inhibition of NF-κB could reduce EBV Ea-R p85 levels by limiting essential transcriptional support.

3′-Azido-3′-deoxythymidine

30516-87-1sc-203319
10 mg
$61.00
2
(1)

3′-Azido-3′-deoxythymidine, a nucleoside reverse transcriptase inhibitor, primarily targets HIV but may exert indirect effects on EBV replication and associated proteins like EBV Ea-R p85 through nucleoside analog mechanisms.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002, a PI3K inhibitor, disrupts signaling pathways involved in cell survival and proliferation. By inhibiting PI3K, it could indirectly affect the cellular environment conducive to EBV Ea-R p85 expression.

Ibrutinib

936563-96-1sc-483194
10 mg
$156.00
5
(0)

Ibrutinib, a Bruton's tyrosine kinase inhibitor, impacts B-cell receptor signaling. Given the role of BCR signaling in EBV latency and reactivation, ibrutinib may indirectly influence EBV Ea-R p85 levels.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Chloroquine, an antimalarial, affects endosomal acidification and autophagy. By modulating autophagic processes, it may impact EBV lifecycle and indirectly affect EBV Ea-R p85 expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin, a flavonoid with anti-inflammatory and antioxidant properties, may influence EBV infection dynamics and associated protein expression, including EBV Ea-R p85, by modulating cellular signaling pathways.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

Disulfiram, an aldehyde dehydrogenase inhibitor, has been shown to have antiviral effects. Its ability to modulate cellular processes could indirectly affect EBV Ea-R p85 by altering viral replication or protein stabilization.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, with anti-inflammatory and antiviral properties, may modulate NF-κB and other signaling pathways relevant to EBV infection and latency, potentially affecting EBV Ea-R p85 expression.

Indirubin

479-41-4sc-201531
sc-201531A
5 mg
25 mg
$114.00
$525.00
4
(1)

Indirubin, a cyclin-dependent kinase inhibitor, impacts cell cycle regulation. Through its effects on cellular proliferation and signaling pathways, it may indirectly suppress EBV Ea-R p85 expression.