EAT-2 Activators
EAT-2 Activators are a diverse group of compounds that enhance the functional activity of EAT-2, primarily through modulation of signaling pathways in immune cells. Sodium Orthovanadate and Pervanadate, both inhibitors of tyrosine phosphatases, maintain the phosphorylation status of key signaling molecules, thereby sustaining activation of pathways where EAT-2 acts as a crucial adaptor molecule. This continuous phosphorylation status potentially amplifies EAT-2-mediated signaling, particularly in natural killer (NK) cells and T cells. Similarly, Okadaic Acid, by inhibiting serine/threonine phosphatases, prolongs signal transduction, enhancing EAT-2's role in immune cell signaling. PKC activators like Prostratin, Bryostatin 1, and Phorbol 12-Myristate 13-Acetate (PMA) further accentuate EAT-2's function by activating protein kinase C, a key player in modulating immune signaling pathways involving EAT-2. This activation is crucial for EAT-2's role in immune cell activation and function.
Additional compounds like Ionomycin and Thapsigargin, which modulate intracellular calcium levels, are also critical in enhancing EAT-2 activity. Ionomycin, as a calcium ionophore, increases calcium levels, essential for the activation of calcium-dependent signaling pathways involving EAT-2. Thapsigargin, by inhibiting the SERCA pump, similarly raises intracellular calcium levels, influencing calcium-dependent signaling where EAT-2 is involved. Forskolin, elevating cAMP levels and activating PKA, indirectly modulates signaling pathways involving EAT-2, particularly in immune cells, adding another layer of regulation to EAT-2 activity. BAPTA-AM, a calcium chelator, further demonstrates the importance of calcium signaling in EAT-2 mediated pathways. Lastly, Genistein and Staurosporine, by modulating tyrosine kinase and various kinases, respectively, contribute to the fine-tuning of signaling pathways crucial for EAT-2's role in immune cell signaling. Collectively, these EAT-2 Activators, through their targeted modulation of phosphorylation status, kinase activity, and intracellular signaling molecules, significantly enhance EAT-2's role in the regulation of immune responses.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate, a tyrosine phosphatase inhibitor, can enhance EAT-2 activity by preventing the dephosphorylation of proteins involved in EAT-2 signaling pathways. This maintenance of phosphorylation status can lead to sustained activation of signaling pathways where EAT-2 is a critical adaptor molecule. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid, a serine/threonine phosphatase inhibitor, indirectly enhances EAT-2 activity by inhibiting phosphatases that dephosphorylate key signaling molecules. This can lead to prolonged signal transduction and enhanced EAT-2 mediated signaling in immune cells. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin, a PKC activator, indirectly enhances EAT-2 activity by activating protein kinase C, which can modulate signaling pathways involving EAT-2, particularly in T cells and NK cells, potentially enhancing immune responses. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1, another PKC activator, enhances EAT-2 function by modulating PKC-mediated signaling pathways. This can lead to an increased role of EAT-2 in immune cell activation and function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin, a calcium ionophore, can enhance EAT-2 activity by increasing intracellular calcium levels, which are important for the activation of certain signaling pathways where EAT-2 is involved, especially in immune cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a PKC activator, indirectly enhances EAT-2 activity by activating protein kinase C, which plays a role in modulating signaling pathways that involve EAT-2, particularly in immune cell activation and signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, by elevating intracellular cAMP levels, indirectly enhances EAT-2's functional activity by activating PKA, which can modulate signaling pathways involving EAT-2 in immune cells. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM, a calcium chelator, indirectly enhances EAT-2 activity by modulating intracellular calcium levels, which are crucial for signaling pathways involving EAT-2, particularly in the context of immune cell function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin, a SERCA pump inhibitor, enhances EAT-2 function by increasing intracellular calcium levels, thereby potentially influencing calcium-dependent signaling pathways where EAT-2 is involved. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, indirectly enhances EAT-2 activity by modulating tyrosine kinase-mediated signaling pathways, potentially leading to an increased role of EAT-2 in immune cell signaling. | ||||||