Ear3 Activators
Ear3, a member of the eosinophil-associated ribonuclease A family, stands as a key player in innate immunity with a multifaceted role encompassing ribonuclease activity, chemotaxis, and mucosal responses. Predicted to enable ribonuclease activity, Ear3 contributes to the degradation of RNA molecules, a function crucial for cellular homeostasis and the regulation of immune responses. Its involvement in chemotaxis implies a role in guiding immune cells to specific locations within the body, facilitating a targeted immune response. Furthermore, Ear3's participation in mucosal responses emphasizes its significance in defending the host against potential threats at the interface between the organism and the external environment.
The activation of Ear3 involves intricate cellular mechanisms and biochemical pathways. Histone acetylation, a process influenced by certain chemicals, creates a conducive chromatin environment that enhances transcription and, consequently, the expression of Ear3. Additionally, cAMP-mediated signaling cascades, modulated by specific chemicals, indirectly contribute to Ear3 activation by influencing pathways associated with chemotaxis and innate immune responses. Modulation of NF-κB signaling, another key pathway, plays a vital role in the regulation of genes associated with innate immunity, indirectly influencing Ear3 expression. The finely tuned interplay of these mechanisms highlights the complexity of Ear3's activation, reflecting its pivotal role in orchestrating innate immune responses. Collectively, these insights into Ear3's function and activation underscore its significance as a molecular player in the intricate web of immune regulation, contributing to the body's defense mechanisms against potential threats.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, through histone acetylation, enhances transcription of genes involved in innate immunity. Ear3, associated with chemotaxis and mucosal responses, is indirectly activated as sodium butyrate alters chromatin structure, fostering a permissive environment for gene expression in relevant pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to elevated cAMP levels. Increased cAMP activates protein kinase A, influencing chemotaxis and innate immune responses. Indirectly, Ear3 expression is promoted through cAMP-mediated signaling cascades, modulating mucosal immune functions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin modulates NF-κB signaling, impacting genes associated with innate immunity. Ear3 is indirectly activated through the inhibition of NF-κB, regulating mucosal immune responses. Quercetin's actions contribute to the promotion of Ear3 expression, affecting cellular processes related to chemotaxis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, up-regulates Ear3 by activating retinoic acid receptors (RARs). RARs translocate to the nucleus, modulating gene expression. Ear3 is indirectly stimulated through RAR-mediated transcriptional events, impacting mucosal immune responses. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate inhibits NF-κB signaling, impacting innate immune response pathways. Ear3 is indirectly activated through the suppression of NF-κB, contributing to the regulation of mucosal immune responses. Sodium salicylate plays a role in promoting Ear3 expression, affecting cellular processes associated with chemotaxis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid inhibits histone deacetylases, influencing chromatin structure and gene expression. Ear3, implicated in innate immune responses, is indirectly activated through valproic acid-mediated modifications in histone acetylation, impacting pathways related to mucosal immunity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, promoting histone acetylation and influencing gene expression. Ear3, involved in chemotaxis and innate immune responses, is indirectly activated as trichostatin A modifies chromatin structure, fostering a conducive environment for gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates NF-κB signaling, impacting pathways associated with chemotaxis. Indirectly, Ear3 is activated through the regulation of NF-κB, influencing mucosal immune responses. Curcumin contributes to the promotion of Ear3 expression, playing a role in the modulation of innate immunity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, influencing histone deacetylation and gene expression. Ear3, involved in innate immune responses, is indirectly stimulated as resveratrol modifies chromatin structure, fostering a conducive environment for gene transcription in relevant pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine acts as a precursor to glutathione, influencing redox homeostasis. Redox-sensitive pathways related to chemotaxis are indirectly affected, promoting Ear3 expression. The activation of Ear3 is mediated through redox-dependent signaling events, contributing to its involvement in innate immune responses. | ||||||