Ear14 Activators
Ear14, a member of the eosinophil-associated ribonuclease A family, plays a pivotal role in orchestrating innate immune responses with a multifaceted functionality. Predicted to enable ribonuclease activity, Ear14 is anticipated to participate in crucial cellular processes, particularly in chemotaxis and innate immune responses within mucosal tissues. Its extracellular localization underscores its involvement in modulating responses at the interface between the host organism and potential environmental challenges. Orthologous to the human RNASE2, Ear14 shares evolutionary significance with a related ribonuclease family member, further emphasizing its essential role in maintaining cellular homeostasis and defense mechanisms. The activation of Ear14 involves a sophisticated interplay of various cellular mechanisms and signaling pathways, contributing to its dynamic engagement in innate immunity. These mechanisms include histone acetylation, cAMP-mediated signaling, and the modulation of key signaling pathways such as NF-κB and Wnt. Histone acetylation, influenced by chemicals like sodium butyrate and trichostatin A, creates a permissive chromatin environment that facilitates gene expression, indirectly promoting Ear14 activation. Forskolin, by activating adenylate cyclase and increasing cAMP levels, stimulates protein kinase A, influencing chemotaxis and innate immune responses and indirectly contributing to Ear14 expression.
Moreover, modulation of NF-κB signaling by chemicals like quercetin and curcumin plays a crucial role in regulating genes associated with innate immunity, indirectly influencing Ear14. Sodium salicylate, through the inhibition of NF-κB, contributes to the suppression of pathways related to mucosal immune responses, indirectly impacting Ear14 activation. Lithium chloride, by activating the Wnt signaling pathway, indirectly influences Ear14 expression, providing another layer of regulatory control over its involvement in innate immunity. Additionally, the redox-sensitive pathways influenced by N-acetyl cysteine and the Nrf2-activating property of sulforaphane contribute to Ear14 activation by impacting cellular redox balance. Collectively, the intricate network of these diverse cellular processes and signaling events highlights the sophisticated regulatory landscape through which Ear14 fulfills its crucial role in orchestrating innate immune responses, particularly within mucosal tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, through histone acetylation, enhances transcription of genes involved in innate immunity. Ear14, associated with chemotaxis and mucosal responses, is indirectly activated as sodium butyrate alters chromatin structure, fostering a permissive environment for gene expression in relevant pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin modulates NF-κB signaling, impacting genes associated with innate immunity. Ear14 is indirectly activated through the inhibition of NF-κB, regulating mucosal immune responses. Quercetin's actions contribute to the promotion of Ear14 expression, affecting cellular processes related to chemotaxis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, up-regulates Ear14 by activating retinoic acid receptors (RARs). RARs translocate to the nucleus, modulating gene expression. Ear14 is indirectly stimulated through RAR-mediated transcriptional events, impacting mucosal immune responses. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium salicylate inhibits NF-κB signaling, impacting innate immune response pathways. Ear14 is indirectly activated through the suppression of NF-κB, contributing to the regulation of mucosal immune responses. Sodium salicylate plays a role in promoting Ear14 expression, affecting cellular processes associated with chemotaxis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid inhibits histone deacetylases, influencing chromatin structure and gene expression. Ear14, implicated in innate immune responses, is indirectly activated through valproic acid-mediated modifications in histone acetylation, impacting pathways related to mucosal immunity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases, promoting histone acetylation and influencing gene expression. Ear14, involved in chemotaxis and innate immune responses, is indirectly activated as trichostatin A modifies chromatin structure, fostering a conducive environment for gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates NF-κB signaling, impacting pathways associated with chemotaxis. Indirectly, Ear14 is activated through the regulation of NF-κB, influencing mucosal immune responses. Curcumin contributes to the promotion of Ear14 expression, playing a role in the modulation of innate immunity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, influencing histone deacetylation and gene expression. Ear14, involved in innate immune responses, is indirectly stimulated as resveratrol modifies chromatin structure, fostering a conducive environment for gene transcription in relevant pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine acts as a precursor to glutathione, influencing redox homeostasis. Redox-sensitive pathways related to chemotaxis are indirectly affected, promoting Ear14 expression. The activation of Ear14 is mediated through redox-dependent signaling events, contributing to its involvement in innate immune responses. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates the Wnt signaling pathway, indirectly impacting Ear14 expression. Wnt pathway modulation influences mucosal immune responses. Lithium chloride's effects on Wnt signaling contribute to the stimulation of Ear14, playing a role in the regulation of innate immune functions. | ||||||