Ear12 Activators
The chemical class known as Ear12 Activators encompasses a diverse range of compounds that can influence the activity of Ear12, a protein associated with eosinophil function. These activators are characterized by their ability to modulate signaling pathways and cellular processes that can lead to the activation of Ear12. They operate through various mechanisms, such as altering intracellular calcium levels, modifying cyclic AMP (cAMP) concentrations, disrupting cellular structures like the Golgi apparatus or actin filaments, and engaging with cell surface receptors to stimulate cellular responses. Through these actions, the activators can encourage the secretion of granule-associated proteins, including ribonucleases, which are key to the functional role of eosinophils in the immune response.
The chemical agents that fall into the category of Ear12 Activators can also interact with the cellular environment to create conditions favorable for the activation of Ear12. This includes facilitating the release of granule contents from eosinophils, affecting protein synthesis, and modulating the signaling cascades that oversee these processes. By altering the intracellular pH and ion concentrations or permeabilizing cell membranes, these activators can induce changes within the cells that can lead to the activation of Ear12. It is the diverse but specific biochemical actions of these molecules that define their classification as Ear12 Activators, each contributing to the overarching process of protein activation within the relevant signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC), which could possibly activate pathways that may enhance the secretion of granule-associated proteins like ribonucleases in eosinophils. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, potentially stimulating the release of eosinophil granules containing ribonucleases, which could possibly activate Ear12. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium concentration, potentially promoting the degranulation of eosinophils, which could possibly activate Ear12. | ||||||
Zymosan | 9010-72-4 | sc-296863 sc-296863A | 100 mg 1 g | $99.00 $599.00 | 1 | |
Zymosan activates the complement system and can stimulate eosinophils, potentially enhancing the release of their granular contents, which could possibly activate Ear12. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This compound disrupts the Golgi apparatus, which can affect the secretion pathways of proteins and might lead to increased cytosolic concentrations of ribonucleases, possibly activating Ear12. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments, which can influence cell shape and secretion processes, possibly affecting ribonuclease release, which could possibly activate Ear12. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that alters intracellular pH and ion concentrations, potentially affecting the secretory pathways of eosinophil ribonucleases, which could possibly activate Ear12. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
This lectin binds to sugar moieties on cell surfaces and can stimulate cells, potentially leading to increased secretion of granule proteins, which could possibly activate Ear12. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO can permeabilize cells and affect various cellular processes, potentially influencing the secretion or activity of ribonucleases, which could possibly activate Ear12. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
Dibutyryl-cAMP acts as a cAMP analog that can diffuse into cells and mimic the effects of cAMP, which might lead to enhanced granule release, possibly activating Ear12. | ||||||