Ear10 Inhibitors
Ear10, a pivotal gene in cellular function, exhibits a multifaceted role encompassing ribonuclease activity, chemotaxis, and innate immune responses in mucosal tissues. Its functional involvement in the extracellular space underscores its significance in orchestrating diverse physiological processes. The predicted orthology to human genes, notably RNASE3, suggests conserved functionality and underscores the potential relevance of findings related to Ear10 in the broader context of mammalian biology. The intricacies of Ear10 function are further underscored by its predicted roles in chemotaxis, hinting at its involvement in cellular migration, and in the innate immune response within mucosal environments, pointing towards its potential role in host defense mechanisms.
Understanding the general mechanisms of Ear10 inhibition unveils a spectrum of intricate cellular pathways targeted by specific chemical entities. These inhibitors act through diverse signaling cascades, modulating the expression and activity of Ear10 indirectly. The inhibition is achieved by disrupting key pathways such as the B-cell receptor signaling pathway, NF-κB pathway, DNA damage response, MAPK pathway, PI3K/AKT pathway, and BET pathway. These pathways represent interconnected cellular networks, and the inhibitors exert their effects by influencing downstream effectors, altering gene expression patterns, and perturbing the delicate balance of cellular signaling. This nuanced approach to inhibition reflects the complexity of cellular regulation and provides a glimpse into the potential regulatory mechanisms governing Ear10 function. Importantly, these inhibitors, through their specific actions on various pathways, offer valuable tools for scientific investigations aiming to dissect the intricate roles of Ear10 in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acalabrutinib | 1420477-60-6 | sc-507392 | 250 mg | $255.00 | ||
Acalabrutinib, a BTK inhibitor, disrupts the B-cell receptor signaling pathway, inhibiting downstream activation of kinases and suppressing Ear10 through the modulation of intracellular signaling cascades. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an IKK inhibitor, interferes with the NF-κB pathway, influencing Ear10 expression by blocking the activation of transcription factors and subsequently impeding inflammatory responses. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a DNA cross-linking agent, indirectly inhibits Ear10 by inducing DNA damage and triggering apoptotic pathways, disrupting cellular processes and affecting gene expression in the target protein. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, modulates the MAPK pathway, impacting Ear10 indirectly by altering signaling cascades and gene expression within the intricate network of cellular responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, disrupts the PI3K/AKT pathway, indirectly influencing Ear10 by modulating downstream effectors and interfering with the regulation of gene expression in relevant cellular contexts. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
(+/-)-JQ1, a BET inhibitor, epigenetically regulates gene expression, indirectly inhibiting Ear10 through modulation of chromatin structure and transcriptional control within the cellular environment. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib, a multi-kinase inhibitor, interferes with RAF/MEK/ERK signaling, indirectly impacting Ear10 by disrupting downstream cascades and modulating gene expression in interconnected pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, influences the mTOR pathway, indirectly inhibiting Ear10 by altering protein synthesis and cell cycle progression, leading to changes in gene expression within the cellular context. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, disrupts the PI3K/AKT pathway, indirectly influencing Ear10 by modulating downstream effectors and interfering with the regulation of gene expression in relevant cellular contexts. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK inhibitor, interferes with the MAPK pathway, indirectly impacting Ear10 by disrupting downstream cascades and modulating gene expression within the intricate network of cellular responses. | ||||||