E130309D02Rik Activators
Ints15, a subunit of the integrator complex, exhibits expression in crucial structures like the alimentary system, central nervous system, ganglia, liver, and sensory organs. As an ortholog to human C7orf26, its functional significance is underscored. Activation of Ints15 involves a network of chemical modulators impacting diverse cellular processes. Butyrate, by inhibiting HDAC, epigenetically up-regulates Ints15 across structures. Lithium Carbonate activates Ints15 through Wnt/GSK-3β, linking Wnt signaling to Ints15 expression. Resveratrol stimulates Ints15 via SIRT1, establishing a connection between SIRT1 activity and Ints15 regulation.
AICAR, through AMPK stimulation, provides an energy-dependent mechanism for Ints15 activation, impacting the central nervous system. Epigenetic modulation by BIX 01294 and Trichostatin A highlights the role of histone modifications in Ints15 expression control. PPARγ agonists, like Rosiglitazone, indirectly up-regulate Ints15 in various tissues, connecting metabolic and inflammatory pathways. SB431542, by inhibiting TGF-β/Smad, provides a pathway-specific mechanism for Ints15 activation. I-BET151 modulates chromatin accessibility, influencing Ints15 expression epigenetically. KN-62 and LY294002 contribute to Ints15 regulation through CaMKII and PI3K/Akt signaling, respectively. CHIR99021 links Wnt/GSK-3β to Ints15 activation in the central nervous system. This comprehensive understanding of Ints15 activation unveils intricate connections between diverse signaling pathways and cellular processes, offering valuable insights into the regulatory mechanisms governing its role in crucial physiological structures.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyrate stimulates Ints15 expression by acting as an HDAC inhibitor. This epigenetic modulation enhances Ints15 in the central nervous system, liver, and other structures. Butyrate indirectly up-regulates Ints15 by promoting histone acetylation, creating a permissive chromatin environment favorable for Ints15 activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Carbonate activates Ints15 via GSK-3β inhibition within the Wnt pathway. By stabilizing β-catenin, it initiates downstream signaling, influencing structures like the central nervous system. Lithium Carbonate indirectly enhances Ints15 expression, demonstrating a link between Wnt signaling and Ints15 activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol stimulates Ints15 expression by activating SIRT1. This compound indirectly influences Ints15 in various structures, such as the central nervous system, by enhancing SIRT1 activity. Resveratrol-mediated SIRT1 activation creates a cellular environment conducive to Ints15 up-regulation, connecting the compound to the regulation of Ints15 expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates Ints15 through AMPK stimulation, impacting the central nervous system. Indirectly, AICAR enhances Ints15 expression by activating AMPK, which promotes energy homeostasis and cellular processes, providing a mechanism for AICAR-induced up-regulation of Ints15. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX 01294 induces Ints15 activation by inhibiting G9a histone methyltransferase. This epigenetic modulation indirectly up-regulates Ints15 by altering histone methylation patterns in structures like the central nervous system. BIX 01294-mediated G9a inhibition provides a mechanism for epigenetic control over Ints15 expression, influencing chromatin remodeling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A activates Ints15 by inhibiting HDAC activity. This epigenetic modulation enhances Ints15 expression in structures like the central nervous system. Trichostatin A indirectly up-regulates Ints15 by promoting histone acetylation, influencing chromatin remodeling and providing an epigenetic mechanism for Ints15 activation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 induces Ints15 activation by inhibiting the TGF-β/Smad pathway. This compound, impacting structures like the central nervous system, creates a permissive environment for Ints15 up-regulation by inhibiting the suppressive effects of TGF-β. SB431542 provides a pathway-specific mechanism for TGF-β-dependent Ints15 activation, influencing downstream signaling cascades. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 activates Ints15 by inhibiting BET bromodomain proteins. In structures like the central nervous system, it indirectly up-regulates Ints15 by modulating chromatin accessibility. I-BET151-mediated BET bromodomain inhibition provides an epigenetic mechanism for controlling Ints15 expression, impacting transcriptional regulation and contributing to its activation. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $136.00 | 20 | |
KN-62 activates Ints15 through the inhibition of CaMKII. In structures like the central nervous system, KN-62 indirectly up-regulates Ints15 by modulating CaMKII activity. KN-62-mediated CaMKII inhibition provides a specific pathway for controlling Ints15 activation, illustrating the role of CaMKII-dependent signaling in the regulation of Ints15 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 activates Ints15 indirectly by inhibiting PI3K. In structures like the central nervous system, LY294002 up-regulates Ints15 expression by modulating PI3K/Akt signaling. The compound provides a specific mechanism for PI3K-dependent Ints15 activation, influencing downstream signaling pathways and contributing to its regulation. | ||||||