E-cadherin Activators
E-cadherin activators belong to a class of compounds that play a pivotal role in cellular adhesion and tissue integrity. E-cadherins themselves are transmembrane glycoproteins that are found on the surface of most epithelial cells, where they mediate calcium-dependent cell-cell adhesion. The activation of E-cadherin is crucial for maintaining the structural integrity of tissues and ensuring proper cell-cell communication. E-cadherin activators are small molecules or peptides that modulate the function of E-cadherin, primarily by enhancing its adhesive properties.
These activators work by strengthening the bonds between adjacent cells, which is particularly important in tissues where strong adhesion is required, such as the epithelial linings of organs like the skin, intestine, and lungs. They do so by promoting the clustering of E-cadherin molecules at cell-cell contact sites. This clustering reinforces the adhesive interactions between cells, contributing to the formation of stable adherens junctions. In addition to their role in adhesion, E-cadherin activators can also influence cell signaling pathways, impacting cellular processes beyond adhesion. In summary, E-cadherin activators are compounds that enhance the adhesive properties of E-cadherin, a critical protein for cell-cell adhesion and tissue integrity. These activators promote the clustering of E-cadherin molecules at cell junctions, reinforcing adhesion between neighboring cells and ensuring the maintenance of tissue structure.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor. It activates E-cadherin by inhibiting ROCK, which in turn reduces actin stress fiber formation and promotes the assembly of adherens junctions. This facilitates the stabilization and activation of E-cadherin-mediated cell adhesion. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl activates E-cadherin through the canonical Wnt/β-catenin pathway. It inhibits glycogen synthase kinase-3β (GSK-3β), preventing β-catenin degradation. Accumulated β-catenin then translocates to the nucleus, where it enhances E-cadherin gene transcription. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a tyrosine phosphatase inhibitor. It can activate E-cadherin by preventing the dephosphorylation of proteins involved in E-cadherin complex formation, thereby stabilizing adherens junctions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC (Histone Deacetylase) inhibitor. It indirectly activates E-cadherin by promoting histone acetylation at the E-cadherin promoter region. This leads to increased E-cadherin gene expression and enhanced cell-cell adhesion. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR99021 is a small molecule that activates E-cadherin by inhibiting GSK-3β in the Wnt/β-catenin pathway, similar to LiCl. This inhibition leads to the accumulation of β-catenin and its subsequent translocation to the nucleus for E-cadherin gene regulation. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 is a small molecule inhibitor of the Wnt pathway. Similar to CHIR99021 and LiCl, it activates E-cadherin by stabilizing β-catenin, leading to increased E-cadherin expression and cell adhesion. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It can activate E-cadherin by promoting the inhibition of histone deacetylases (HDACs) and enhancing E-cadherin gene transcription, resulting in increased E-cadherin levels and improved cell adhesion. | ||||||