E-cadherin Antibody (G-10): sc-8426
- E-cadherin Antibody (G-10) is a mouse monoclonal IgG1 κ E-cadherin antibody, cited in 629 publications, provided at 200 µg/ml
- raised against amino acids 600-707 mapping within the extracellular domain of E-cadherin of human origin
- E-cadherin Antibody (G-10) is recommended for detection of E-cadherin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-E-cadherin Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for E-cadherin Antibody (G-10) for WB and IHC(P) applications. This reagent is now offered in a bundle with E-cadherin Antibody (G-10) (see ordering information below).
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E-cadherin Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects E-cadherin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-E-cadherin antibody (G-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. E-cadherin, also known as CD324 or CDH1, plays a crucial role in cell adhesion, which is vital for maintaining tissue integrity and facilitating morphogenetic processes during embryonic development. E-cadherin protein is primarily located at the cell membrane, where E-cadherin forms adherens junctions with neighboring cells, thereby contributing to the structural stability of tissues. E-cadherin presence at these junctions is essential for the regulation of cellular signaling pathways and the maintenance of epithelial cell polarity. Disruption of E-cadherin function is associated with various pathological conditions, including cancer metastasis, where loss of cell adhesion allows for increased cellular motility and invasion. E-cadherin′s interaction with cytoplasmic proteins, such as β-catenin, further underscores E-cadherin′s importance in cellular communication and signaling, making E-cadherin monoclonal antibody (G-10) a valuable tool for studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
E-cadherin Antibody (G-10) References:
- Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. | Umbas, R., et al. 1992. Cancer Res. 52: 5104-9. PMID: 1516067
- Genomic organization and chromosomal mapping of the mouse P-cadherin gene. | Hatta, M., et al. 1991. Nucleic Acids Res. 19: 4437-41. PMID: 1886768
- [Surgical therapy of breast cancer]. | Hirsch, HA. 1978. Gynakol Rundsch. 18: 132-41. PMID: 207622
- The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | Takeichi, M. 1988. Development. 102: 639-55. PMID: 3048970
- Desmosomal cadherins: another growing multigene family of adhesion molecules. | Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
- Cadherins and catenins: interactions and functions in embryonic development. | Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
- Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. | Tanihara, H., et al. 1994. Cell Adhes Commun. 2: 15-26. PMID: 7982033
- Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. | Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
- Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. | Hinck, L., et al. 1994. J Cell Biol. 125: 1327-40. PMID: 8207061
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-cadherin Antibody (G-10) | sc-8426 | 200 µg/ml | $316.00 | |||
E-cadherin Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-525454 | 200 µg Ab; 10 µg BP | $354.00 | |||
E-cadherin Antibody (G-10) AC | sc-8426 AC | 500 µg/ml, 25% agarose | $416.00 | |||
E-cadherin Antibody (G-10) HRP | sc-8426 HRP | 200 µg/ml | $316.00 | |||
E-cadherin Antibody (G-10) FITC | sc-8426 FITC | 200 µg/ml | $330.00 | |||
E-cadherin Antibody (G-10) PE | sc-8426 PE | 200 µg/ml | $343.00 | |||
E-cadherin Antibody (G-10) Alexa Fluor® 488 | sc-8426 AF488 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (G-10) Alexa Fluor® 546 | sc-8426 AF546 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (G-10) Alexa Fluor® 594 | sc-8426 AF594 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (G-10) Alexa Fluor® 647 | sc-8426 AF647 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (G-10) Alexa Fluor® 680 | sc-8426 AF680 | 200 µg/ml | $357.00 | |||
E-cadherin Antibody (G-10) Alexa Fluor® 790 | sc-8426 AF790 | 200 µg/ml | $357.00 |