DYNC2LI1 Activators
DYNC2LI1 (Dynein Cytoplasmic 2 Light Intermediate Chain 1) Activators are a class of chemical compounds that play a pivotal role in regulating cellular processes by modulating the activity of the dynein motor protein complex. Dyneins are molecular motor proteins that move along microtubules within cells and are essential for various intracellular transport processes, including the movement of organelles, vesicles, and other cellular cargo. DYNC2LI1 is one of the key components of the dynein complex and serves as a light intermediate chain. Activators of DYNC2LI1 are small molecules or chemical compounds that specifically interact with and enhance the function of this dynein subunit.
These activators work by binding to DYNC2LI1 and promoting its association with other dynein subunits, thus enhancing the assembly and stability of the dynein motor complex. This, in turn, results in increased dynein activity, facilitating the intracellular transport of various cargoes within the cell. The modulation of DYNC2LI1 activity can have profound effects on cellular processes such as organelle positioning, cell division, and intracellular trafficking. Researchers are actively studying DYNC2LI1 activators to gain a better understanding of their mechanisms and potential applications in basic cell biology research. By elucidating the precise mechanisms by which these activators enhance dynein function, scientists aim to uncover new insights into cellular transport processes and potentially develop novel tools for manipulating cellular functions for research purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Indirectly increases DYNC2LI1 by directly stabilizing microtubules, providing a stable track for dynein motors to transport cellular cargo. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Indirectly activates DYNC2LI1 by disrupting microtubules, which can destabilize the microtubule network used by dynein for intracellular transport. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Indirectly activates DYNC2LI1 by inhibiting microtubule polymerization, leading to the disruption of microtubules that dynein relies on for its transport functions. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
May indirectly increase DYNC2LI1 by causing DNA damage and cellular stress responses, which could affect the regulation of dynein or its associated proteins. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Potentially indirectly increase DYNC2LI1 by inducing DNA damage and cellular stress responses, which may alter the cellular environment impacting dynein function. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
Acts indirectly on DYNC2LI1 by inhibiting HSP90, a chaperone protein, which may influence the stability and increase the function of DYNC2LI1 and its associated partners. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
geldanamycin indirectly affects DYNC2LI1 by inhibiting HSP90, potentially disrupting the proper folding and stability of DYNC2LI1 and related proteins increasing activity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Indirectly increases DYNC2LI1 by binding to tubulin and promoting microtubule depolymerization, disrupting the microtubule tracks used by dynein for intracellular transport. | ||||||