DYNC2LI1 Inhibitors
DYNC2LI1 inhibitors belong to a chemical class of compounds that target the DYNC2LI1 protein. DYNC2LI1, also known as dynein cytoplasmic 2 light intermediate chain 1, is a component of the cytoplasmic dynein-2 complex. This complex is a motor protein that plays a crucial role in intracellular transport along microtubules. It is involved in various cellular processes, such as vesicle and organelle trafficking, spindle positioning during cell division, and cilia and flagella movement.
By inhibiting DYNC2LI1, these compounds may interfere with the function of the cytoplasmic dynein-2 complex and disrupt its ability to transport cargo along microtubules. This could potentially affect cellular processes that rely on proper intracellular transport, leading to altered cell function. Understanding the role of DYNC2LI1 inhibitors is essential for exploring the mechanisms of intracellular transport and its significance in various cellular functions. However, the specific applications and potential implications of DYNC2LI1 inhibitors require further research to comprehensively understand their effects on cellular processes and biological systems.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $189.00 | 4 | |
Although primarily known for its selective inhibition of the PI3Kδ isoform, its impact on DYNC2LI1 would hypothetically involve interference with cellular signaling pathways that indirectly affect microtubule dynamics and dynein motor function, potentially altering cellular transport mechanisms crucial for cell survival and proliferation. | ||||||
BAY 80-6946 | 1032568-63-0 | sc-503264 | 5 mg | $551.00 | ||
Copanlisib's role as a PI3Kδ inhibitor suggests that any hypothetical inhibition of DYNC2LI1 could involve modulation of signaling pathways that indirectly influence microtubule stability and dynein-dependent transport processes, which are vital for maintaining cellular architecture and intracellular trafficking. | ||||||
IPI 145 | 1201438-56-3 | sc-488318 | 5 mg | $311.00 | ||
Inhibiting both PI3Kδ and PI3Kγ isoforms, Duvelisib might hypothetically affect DYNC2LI1 function by altering signaling cascades that regulate microtubule dynamics, potentially impacting the dynein motor complex and its associated proteins, thereby affecting cellular transport and communication. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $173.00 $230.00 $275.00 $332.00 | 9 | |
As a pan-PI3K inhibitor, any hypothetical interaction with DYNC2LI1 by Buparlisib would likely involve broad modulation of signaling pathways that could indirectly affect microtubule-associated processes and dynein motor activity, impacting cellular processes such as division and trafficking. | ||||||
BYL719 | 1217486-61-7 | sc-391001 sc-391001A sc-391001B sc-391001C sc-391001D sc-391001E | 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $383.00 $585.00 $740.00 $1169.00 $4902.00 $9186.00 | 2 | |
Targeting PI3Kα specifically, Alpelisib's hypothetical impact on DYNC2LI1 could involve changes in cell signaling pathways that indirectly influence microtubule dynamics and dynein function, affecting processes like intracellular transport and cellular motility. | ||||||
PI 3-Kβ Inhibitor VI, TGX-221 | 663619-89-4 | sc-203190 | 1 mg | $437.00 | ||
By selectively targeting PI3Kβ, TGX-221's hypothetical impact on DYNC2LI1 would likely involve modulation of signaling pathways that indirectly influence dynein motor function and microtubule stability, affecting cellular transport and signaling. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
Being a pan-PI3K inhibitor, ZSTK474's hypothetical interaction with DYNC2LI1 could involve broad modulation of cellular signaling pathways that indirectly affect microtubule-associated processes and dynein motor activity, potentially influencing cell division and intracellular transport. | ||||||
A66 | 1166227-08-2 | sc-364394 sc-364394A | 5 mg 50 mg | $255.00 $1455.00 | ||
The selective inhibition of PI3Kα by A66 suggests that its hypothetical impact on DYNC2LI1 could involve alterations in signaling pathways that indirectly influence microtubule stability and the function of the dynein motor complex, affecting processes crucial for cellular transport and morphology. | ||||||