DUSP28 Activators
DUSP28 activators are chemical compounds that enhance the function of DUSP28, a dual-specificity phosphatase, through direct or indirect interaction with the protein and the pathways it is involved in. Sodium orthovanadate, okadaic acid, calyculin A, norcantharidin, cantharidin, sodium fluoride, phosphoramidon, phenylarsine oxide, staurosporine, sanguinarine, forskolin, and epigallocatechin gallate indirectly enhance DUSP28 function by inhibiting phosphatases or kinases that share substrates with DUSP28 or by enhancing the levels of substrates of DUSP28. These inhibitors of phosphatases or kinases increase the phosphorylation status of the substrates of DUSP28, leading to their enhanced activation. Such a process can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation.
Among the list, sodium orthovanadate, okadaic acid, calyculin A, norcantharidin, cantharidin, sodium fluoride, and phenylarsine oxide inhibit protein phosphatases, including types 1 and 2A, serine/threonine phosphatases, and tyrosine phosphatases. These inhibitors lead to an increase in the phosphorylation status of the substrates of DUSP28, thereby indirectly enhancing its function. Phosphoramidon, on the other hand, inhibits neutral endopeptidase, leading to an increase in the levels of peptides that might be DUSP28 substrates. Staurosporine, a potent inhibitor of protein kinases, can indirectly enhance the function of DUSP28 by inhibiting kinases that compete with DUSP28 for the same substrates. Finally, forskolin, an activator of adenylate cyclase, indirectly enhances DUSP28 function by activating cAMP-dependent protein kinases that phosphorylate substrates of DUSP28.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a potent inhibitor of protein tyrosine phosphatases, including DUSP28. By inhibiting DUSP28's phosphatase activity, sodium orthovanadate indirectly enhances the phosphorylation status of the substrates of DUSP28, leading to their enhanced activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. DUSP28's activity can be indirectly enhanced by okadaic acid, as it will increase the phosphorylation status of DUSP28 substrates, leading to their enhanced activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, calyculin A can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $111.00 | 2 | |
Norcantharidin is a protein phosphatase 2A inhibitor. By inhibiting protein phosphatase 2A, norcantharidin can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, cantharidin can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride is an inhibitor of serine/threonine phosphatases. By inhibiting these phosphatases, sodium fluoride can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $195.00 $620.00 | 8 | |
Phosphoramidon is a neutral endopeptidase inhibitor. By inhibiting neutral endopeptidase, phosphoramidon can indirectly enhance the function of DUSP28 by increasing the levels of peptides that might be DUSP28 substrates, leading to their enhanced activation. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine oxide is an inhibitor of tyrosine phosphatases. By inhibiting these phosphatases, phenylarsine oxide can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Although it inhibits protein kinases, staurosporine can indirectly enhance the function of DUSP28 by inhibiting kinases that compete with DUSP28 for the same substrates, leading to their enhanced activation. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium is an inhibitor of protein phosphatase 2C. By inhibiting protein phosphatase 2C, sanguinarine can indirectly enhance the function of DUSP28 by increasing the phosphorylation status of its substrates, leading to their enhanced activation. | ||||||