DUSP13 Activators
Dual Specificity Phosphatase 13 (DUSP13), also known as TMDP, is a member of the dual-specificity protein phosphatases. These enzymes are key regulators in cellular signaling, with the ability to dephosphorylate both tyrosine and serine/threonine residues on their substrate proteins. DUSP13 is part of a subfamily of DUSPs that can inactivate their target proteins, thus serving as a critical off-switch in cellular signaling pathways.
DUSP13 is involved in the regulation of several important physiological processes, including cell growth, differentiation, and apoptosis, by modulating the activity of mitogen-activated protein kinases (MAPKs). MAPKs are pivotal in transducing extracellular signals into intracellular responses. By deactivating MAPKs, DUSP13 can dampen signal transduction, ensuring that cellular responses are appropriately regulated and do not become excessive.The expression of DUSP13 is tissue-specific, with notable levels in skeletal muscle and the heart, suggesting a specialized role in the unique signaling environments of these tissues. Research has indicated that DUSP13 may have a role in protecting against cardiac hypertrophy, a condition where heart muscle cells enlarge, which can lead to heart disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May regulate gene expression through retinoic acid receptors, potentially affecting DUSP13. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP, which may modulate transcription factors and influence DUSP13 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids can regulate gene expression, potentially altering DUSP13 levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which may lead to transcriptional regulation of DUSP13. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Inhibits NF-κB signaling, potentially influencing DUSP13 transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates transcription factors and signaling pathways, which may alter DUSP13 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences GSK-3 signaling, potentially affecting DUSP13 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen receptor signaling can impact gene expression, possibly including DUSP13. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPAR agonists modulate the expression of genes involved in metabolism and inflammation, potentially affecting DUSP13. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
Involved in cellular signaling and may regulate the expression of genes like DUSP13. | ||||||