DUSP13 Antibody (C-4): sc-376417
- DUSP13 Antibody (C-4) is a mouse monoclonal IgG1 κ DUSP13 antibody provided at 200 µg/ml
- raised against amino acids 1-138 mapping at the N-terminus of DUSP13 of human origin
- DUSP13 Antibody (C-4) is recommended for detection of DUSP13 of human origin by WB, IP, IF and ELISA
- Anti-DUSP13 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DUSP13 Antibody (C-4). This work is in progress.
DUSP13 Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects DUSP13 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DUSP13 (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DUSP13, also known as TMDP or SKRP4, plays a crucial role in regulating mitogen-activated protein (MAP) kinases, which are essential for signal transduction pathways that respond to various stimuli and mediate significant physiological and pathological changes within cells. DUSP13 is primarily located in the cytoplasm and is abundantly expressed in the testis, with lower levels found in skeletal muscle. DUSP13 localization allows for precise regulation of MAP kinases during critical processes such as spermatogenesis, where DUSP13 influences the differentiation and maturation of testicular germ cells. By dephosphorylating specific phosphothreonine and phosphotyrosine residues on MAP kinases, DUSP13 helps maintain cellular homeostasis and modulates responses to growth factors and cellular stress, thereby playing a significant role in reproductive health and development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DUSP13 Antibody (C-4) References:
- Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. | Nakamura, K., et al. 1999. Biochem J. 344 Pt 3: 819-25. PMID: 10585869
- Dual specificity phosphatases: a gene family for control of MAP kinase function. | Camps, M., et al. 2000. FASEB J. 14: 6-16. PMID: 10627275
- Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. | Chen, HH., et al. 2004. J Biol Chem. 279: 41404-13. PMID: 15252030
- Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. | Kim, SJ., et al. 2007. Proteins. 66: 239-45. PMID: 17044055
- Dual-specificity phosphatases: critical regulators with diverse cellular targets. | Patterson, KI., et al. 2009. Biochem J. 418: 475-89. PMID: 19228121
- hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. | Martell, KJ., et al. 1995. J Neurochem. 65: 1823-33. PMID: 7561881
- An emerging family of dual specificity MAP kinase phosphatases. | Keyse, SM. 1995. Biochim Biophys Acta. 1265: 152-60. PMID: 7696343
- Functional studies of dual-specificity phosphatases. | Sun, H. 1998. Methods Mol Biol. 84: 307-18. PMID: 9666459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DUSP13 Antibody (C-4) | sc-376417 | 200 µg/ml | $322.00 | |||
DUSP13 Antibody (C-4) AC | sc-376417 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DUSP13 Antibody (C-4) HRP | sc-376417 HRP | 200 µg/ml | $322.00 | |||
DUSP13 Antibody (C-4) FITC | sc-376417 FITC | 200 µg/ml | $336.00 | |||
DUSP13 Antibody (C-4) PE | sc-376417 PE | 200 µg/ml | $349.00 | |||
DUSP13 Antibody (C-4) Alexa Fluor® 488 | sc-376417 AF488 | 200 µg/ml | $364.00 | |||
DUSP13 Antibody (C-4) Alexa Fluor® 546 | sc-376417 AF546 | 200 µg/ml | $364.00 | |||
DUSP13 Antibody (C-4) Alexa Fluor® 594 | sc-376417 AF594 | 200 µg/ml | $364.00 | |||
DUSP13 Antibody (C-4) Alexa Fluor® 647 | sc-376417 AF647 | 200 µg/ml | $364.00 | |||
DUSP13 Antibody (C-4) Alexa Fluor® 680 | sc-376417 AF680 | 200 µg/ml | $364.00 | |||
DUSP13 Antibody (C-4) Alexa Fluor® 790 | sc-376417 AF790 | 200 µg/ml | $364.00 |