Duffy Activators
ACKR1 Activators encompass a selection of chemical compounds that indirectly enhance the receptor's activity through cAMP modulation and subsequent influence on G protein-coupled receptor pathways. For instance, Prostaglandin E2 and PGE1 bind to their respective receptors to increase cAMP levels, which in turn may lead to conformational changes in ACKR1, augmenting its interaction with chemokines and facilitating its signaling functions. Similarly, Forskolin, Salbutamol, and Isoproterenol, through their distinct interactions with adenylate cyclase or specific adrenergic receptors, elevate intracellularcAMP concentrations, thereby potentiating ACKR1's capacity for chemokine engagement and signaling. The elevated cAMP levels resulting from the actions of these compounds are critical for enhancing the ACKR1-mediated pathways, as they play a pivotal role in the regulation of G protein-coupled receptors. Moreover, Rolipram and IBMX inhibit phosphodiesterase enzymes, preventing the breakdown of cAMP, which can indirectly augment ACKR1 activity by stabilizing the signaling milieu in which the receptor operates. Adenosine, through its receptors, and NECA, as an adenosine receptor agonist, also contribute to the elevated cAMP landscape, further promoting ACKR1's functional state.
The dopaminergic and adrenergic systems intersect with the cAMP-mediated pathways to modulate the activity of ACKR1. Dopamine, through D1-like receptors, and Epinephrine, engaging adrenergic receptors, increase cAMP production, which is a crucial secondary messenger for the modulation of G protein-coupled receptor activity, including that of ACKR1. Iloprost, mimicking prostacyclin PGI2, activates IP receptors to raise cAMP levels, which can result in an enhancement of ACKR1 function by influencing the G protein-coupled receptor signaling. Each activator, though distinct in its primary action, converges on the cAMP pathway, illustrating a complex yet coherent mechanism by which ACKR1 activity is indirectly upregulated.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 binds to the prostaglandin E receptor, which can lead to adenylate cyclase activation and increased cAMP levels. Elevated cAMP may enhance ACKR1 signaling by promoting receptor conformational changes that facilitate its interactions with chemokines. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, thereby increasing intracellular cAMP levels. Higher cAMP levels can potentiate ACKR1 activity by improving its ability to bind its chemokine ligands or by enhancing G protein-coupled receptor signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that can elevate cAMP levels in cells, which may indirectly enhance ACKR1 activation through cAMP-dependent signaling pathways that affect G protein-coupled receptor function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which breaks down cAMP. Inhibition of PDE4 prevents cAMP degradation, thereby enhancing the signaling pathways that could indirectly activate ACKR1. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost is a synthetic analog of prostacyclin PGI2, which activates IP receptors leading to increased cAMP in cells. This elevation in cAMP might enhance ACKR1 signaling by modulating G protein-coupled receptor pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, thereby preventing the breakdown of cAMP and cGMP. Elevated levels of these cyclic nucleotides can indirectly promote ACKR1 function by affecting the signaling environment of G protein-coupled receptors. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with its receptors to increase cAMP levels, which could indirectly enhance ACKR1 activity by altering the receptor's ability to engage with chemokines in G protein-coupled signaling pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, through its action on adrenergic receptors, can lead to increased intracellular cAMP, which may indirectly promote ACKR1 activity by modulating G protein-coupled receptor signaling. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
PGE1 binds to prostaglandin receptors, leading to increased cAMP in cells, which can indirectly promote ACKR1 activity by affecting the G protein-coupled signaling environment that ACKR1 functions within. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a selective β2-adrenergic receptor agonist that can increase cAMP levels in cells, potentially enhancing ACKR1 function by modulating G protein-coupled receptor-dependent signaling pathways. | ||||||