DUE-B Activators
DNA Unwinding Element Binding protein (DUE-B) is a protein involved in the initiation of DNA replication, a critical cellular process that ensures accurate duplication of the genetic material prior to cell division. DUE-B specifically recognizes and binds to DNA unwinding elements (DUEs), which are A/T-rich sequences commonly found at origins of replication. By interacting with these sequences, DUE-B facilitates the unwinding of DNA, an essential step for the formation of the replication fork where the DNA helicase and other replication proteins assemble to begin synthesizing new DNA strands.
DUE-B's role is particularly crucial during the early stages of replication initiation. It associates with other pre-replicative complex proteins to prepare the DNA for unwinding. The interaction of DUE-B with the DNA is thought to alter the local DNA structure, making it more accessible for the helicase and other replication factors. This is an important regulatory mechanism ensuring that replication begins at the right place and time within the cell cycle.The activity of DUE-B is tightly regulated to prevent re-replication, which can lead to genomic instability and contribute to tumorigenesis. There are checkpoints in place that control the loading and activation of DUE-B and the other pre-replicative proteins. Post-translational modifications, such as phosphorylation, can influence the activity and interactions of DUE-B, adding an additional layer of regulation to its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor, affecting DNA replication, potentially impacting DUE-B's role in this process. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis and potentially influencing DUE-B activity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib is a CDK4/6 inhibitor, affecting cell cycle progression and potentially influencing DUE-B's regulatory role. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is a nucleoside analog used in chemotherapy that inhibits DNA synthesis, potentially impacting DUE-B activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, is involved in the DNA damage response and could indirectly affect DUE-B's role in DNA replication. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can inhibit ATM and ATR kinases, affecting the DNA damage response and potentially influencing DUE-B. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR inhibitors affect the response to DNA damage and replication stress, potentially impacting DUE-B activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, affects cell growth and division, potentially influencing DUE-B's regulatory role. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a CHK inhibitor, affecting cell cycle checkpoints and potentially impacting DUE-B activity. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
ATM inhibitors affect the DNA damage response, potentially impacting DUE-B's role in DNA replication. | ||||||