DUB1A Inhibitors
DUB1A inhibitors are a class of chemical compounds designed to inhibit the activity of DUB1A, a deubiquitinating enzyme that plays a significant role in the regulation of protein ubiquitination within the ubiquitin-proteasome system (UPS). Ubiquitination is a post-translational modification where ubiquitin molecules are attached to proteins, often marking them for degradation by the proteasome. DUB1A, like other deubiquitinating enzymes, functions to remove ubiquitin chains from target proteins, thus preventing their degradation and regulating their cellular levels and functions. This process is crucial for maintaining protein homeostasis, controlling the degradation of misfolded or damaged proteins, and regulating various signaling pathways. By inhibiting DUB1A, these compounds block the removal of ubiquitin, leading to the continued ubiquitination and subsequent degradation of proteins that DUB1A typically acts upon.
The structural design of DUB1A inhibitors is focused on targeting the enzyme's catalytic domain, which is responsible for cleaving ubiquitin from substrate proteins. These inhibitors may employ competitive inhibition, binding directly to the active site and preventing the interaction between DUB1A and its ubiquitinated targets, or they may act through allosteric mechanisms that induce conformational changes, reducing the enzyme's catalytic efficiency. Studying DUB1A inhibitors provides valuable insights into the specific substrates regulated by DUB1A and how its inhibition impacts protein stability, turnover, and broader cellular processes. The role of DUB1A in modulating protein ubiquitination links it to a wide range of cellular functions, from cell cycle control to stress responses, and understanding its inhibition helps clarify the complex regulatory networks that rely on deubiquitination to maintain cellular equilibrium.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
Thiol-dependent deubiquitinase inhibitor impacting Usp17lb. WP1130 disrupts the function of Usp17lb, preventing thiol-dependent deubiquitination. This inhibition hampers the enzymatic activity essential for protein deubiquitination within the endoplasmic reticulum membrane. | ||||||
P005091 | 882257-11-6 | sc-478535 | 10 mg | $155.00 | ||
Usp inhibitor affecting protein deubiquitination. P5091 inhibits Usp17lb, disrupting its thiol-dependent deubiquitinase activity. The inhibition impedes Usp17lb's role in deubiquitinating proteins, potentially altering cellular processes related to protein homeostasis within the endoplasmic reticulum membrane. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
Deubiquitinase inhibitor influencing Usp17lb. NSC697923 disrupts thiol-dependent deubiquitination, inhibiting Usp17lb and preventing its enzymatic activity. This inhibition impacts protein deubiquitination processes within the endoplasmic reticulum membrane, potentially altering cellular homeostasis. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
Ubiquitin-specific protease inhibitor affecting Usp17lb. IU1 inhibits Usp17lb, preventing its thiol-dependent deubiquitinase activity. This inhibition hampers the enzymatic processes crucial for protein deubiquitination within the endoplasmic reticulum membrane, potentially influencing cellular protein homeostasis. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Autophagy inhibitor affecting Usp17lb. Spautin-1 disrupts autophagy processes regulated by Usp17lb, indirectly influencing its thiol-dependent deubiquitination activity. This disruption potentially impacts protein deubiquitination within the endoplasmic reticulum membrane, altering cellular homeostasis. | ||||||
UCH-L1 Inhibitor Inhibitor | 668467-91-2 | sc-356182 | 10 mg | $204.00 | 1 | |
Deubiquitinase inhibitor impacting Usp17lb. LDN-57444 disrupts the thiol-dependent deubiquitination activity of Usp17lb, inhibiting its enzymatic function. This inhibition influences protein deubiquitination within the endoplasmic reticulum membrane, potentially altering cellular homeostasis related to Usp17lb. | ||||||
Glucocorticoid Receptor Modulator, CpdA | 14593-25-0 | sc-221677 | 25 mg | $150.00 | 2 | |
Deubiquitinase inhibitor affecting Usp17lb. CpdA disrupts the thiol-dependent deubiquitination activity of Usp17lb, inhibiting its enzymatic function. This inhibition potentially influences protein deubiquitination processes within the endoplasmic reticulum membrane, altering cellular homeostasis related to Usp17lb. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
Broad-spectrum deubiquitinase inhibitor affecting Usp17lb. PR-619 disrupts the enzymatic activity of Usp17lb, preventing thiol-dependent deubiquitination. This inhibition potentially alters protein deubiquitination processes within the endoplasmic reticulum membrane, influencing cellular homeostasis. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
HB-EGF inhibitor impacting cellular processes downstream of Usp17lb. This compound indirectly influences Usp17lb by disrupting HB-EGF signaling, potentially altering protein deubiquitination processes within the endoplasmic reticulum membrane and cellular homeostasis regulated by Usp17lb. | ||||||