DTHD1 Activators
DTHD1 activators are a class of chemical compounds that target the DTHD1 enzyme, a protein which plays a significant role in cellular processes. The acronym DTHD1 stands for "Deoxythymidylate Hydroxymethylase Domain-containing protein 1", an enzyme that has been identified as crucial in certain biochemical pathways within cells. The activators are designed to interact with and modulate the activity of this enzyme. At the molecular level, these compounds bind to the active site or other regulatory sites of the DTHD1 enzyme, thereby influencing its catalytic activity. The precise mechanisms by which these activators work can vary, but they typically involve changes in the enzyme's conformation, affecting its interaction with substrates or cofactors, and thereby modulating the rate of the reactions that the enzyme catalyzes.
The structure-activity relationship (SAR) of DTHD1 activators is an area of intense study, as understanding the interaction between these compounds and the DTHD1 enzyme is key to refining their efficacy and specificity. Chemical modifications to the activator molecules can result in different degrees of interaction with the enzyme, which in turn can lead to variations in the enzyme's activity. The molecular design of DTHD1 activators often involves the inclusion of functional groups that are capable of forming bonds or interactions with amino acid residues within the enzyme's active site. Researchers use various techniques, including computational modeling and crystallography, to elucidate the binding modes of these compounds and to inform the design of molecules with improved properties. As with many areas of chemical research, the development of DTHD1 activators is driven by a deep understanding of chemistry and biochemistry, with a focus on the intricate dance of molecular interactions that govern enzyme function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA). PKA can phosphorylate target proteins, potentially including DTHD1, thereby enhancing its functional activity in the cell. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP acts as a cAMP analog and can directly activate PKA. Activated PKA may phosphorylate DTHD1, or proteins that regulate DTHD1 activity, leading to an enhancement of DTHD1 function in the cell without affecting its transcription or translation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium levels can activate calcium-dependent kinases such as calmodulin-dependent kinase (CaMK), which might then enhance the activity of DTHD1 by phosphorylation or conformational change. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activated PKC can phosphorylate a wide range of target proteins, potentially including DTHD1, which may lead to the enhancement of DTHD1's activity within its specific signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its specific G-protein-coupled receptors (GPCRs), which can activate downstream signaling cascades such as the PI3K/Akt pathway. This activation could lead to phosphorylation events or other modifications that enhance the activity of DTHD1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinases (SAPKs), such as JNK. JNK activation may lead to the phosphorylation of substrates that influence DTHD1 activity, thereby indirectly enhancing its function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). The subsequent increase in cytosolic calcium can activate calcium-dependent signaling pathways that might upregulate DTHD1 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, similar to ionomycin. This increase can activate downstream calcium-dependent proteins and pathways that may enhance the activity of DTHD1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to the alteration of downstream signaling pathways. This perturbation might result in feedback mechanisms that upregulate the activity of DTHD1 as the cell attempts to compensate for PI3K inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 may lead to compensatory activation of alternative pathways or feedback mechanisms that can enhance the activity of DTHD1. | ||||||