DSN1 Activators
DSN1," or "Dosage Suppression of NNF1," is a gene that encodes a protein component of the kinetochore complex. The kinetochore is a vital structure composed of proteins assembled on the centromere, which is the part of a chromosome that links sister chromatids. During cell division, specifically mitosis and meiosis, kinetochores are responsible for the attachment of chromosomes to the spindle microtubules, enabling their accurate segregation into daughter cells.The DSN1 protein is a part of the MIS12 complex within the kinetochore, which is essential for the proper assembly and function of the kinetochore. It serves as a crucial connection point between the inner kinetochore proteins, which bind directly to the centromeric DNA, and the outer kinetochore proteins, which interact with the spindle microtubules.
DSN1's role is not merely structural; it is also implicated in the signaling pathways that ensure the correct attachment of the kinetochore to the spindle fibers. This includes the spindle assembly checkpoint, a critical surveillance mechanism that prevents the onset of anaphase until all chromosomes are properly attached to the spindle, thus ensuring accurate chromosome segregation and genomic stability.Mutations or dysregulation of the DSN1 gene or protein can lead to chromosomal missegregation, aneuploidy, and contribute to the development of various cancers.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can indirectly affect DSN1 by altering kinetochore-microtubule interactions during cell division. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule-depolymerizing agent, Nocodazole can influence spindle assembly and indirectly impact DSN1 function in the kinetochore. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
An inhibitor of the kinesin Eg5, Monastrol disrupts spindle formation, potentially affecting DSN1's role in the kinetochore. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits microtubule polymerization, indirectly affecting DSN1's function in chromosome segregation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
A microtubule-destabilizing agent, Vinblastine can influence kinetochore function and indirectly impact DSN1. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
A specific inhibitor of Eg5, this compound disrupts mitotic spindle dynamics, potentially impacting DSN1 function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor, ZM447439, can alter kinetochore function, indirectly affecting DSN1. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
A PLK1 inhibitor, BI 2536 can disrupt spindle assembly and indirectly influence DSN1 in the kinetochore. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An Aurora A kinase inhibitor, Alisertib can affect spindle assembly and kinetochore function, indirectly impacting DSN1. | ||||||