DSEL Activators
DSEL activators represent a diverse class of compounds that interact with specific signaling pathways, leading to the enhancement of DSEL's functional activity. Forskolin and Isoproterenol, through their activation of adenylate cyclase and β-adrenergic receptors respectively, lead to increased cAMP levels in the cell, which activates PKA. PKA is known to phosphorylate a broad range of substrates, and this can include proteins within the DSEL signaling network, thereby enhancing DSEL's activity. Similarly, compounds like IBMX and cAMP itself, by increasing intracellular levels of cAMP, support the activation of PKA and subsequent phosphorylation events that can enhance DSEL's activity.
Compounds such as EGF and VEGF function by activating their respective tyrosine kinase receptors, leading to downstream signaling cascades like MAPK/ERK and PI3K/AKT pathways. These pathways are crucial for a variety of cellular processes, and their activation can lead to the phosphorylation of proteins that are involved in DSEL's signaling network. On the other hand, nitric oxide donors like SNAP and calcium ionophores such as A23187 influence other types of cellular signaling pathways-cGMP and calcium signaling, respectively. The activation of soluble guanylyl cyclase by nitric oxide increases cGMP levels, which in turn activates PKG. PKG, much like PKA, is capable of phosphorylating proteins, potentially affecting those associated with DSEL's functionality. Calcium ionophores increase intracellular calcium, which activates a suite of calcium-dependent kinases that can modify proteins interacting with or regulating DSEL.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpenoid that activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various proteins, thus enhancing DSEL activity through phosphorylation-dependent mechanisms. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine and β-adrenergic agonist that elevates intracellular cAMP by activating β-adrenergic receptors. This leads to PKA activation and subsequent phosphorylation of proteins that are part of DSEL's signaling pathway. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide, which activates soluble guanylyl cyclase, increasing cGMP levels and activating PKG. PKG then can phosphorylate proteins within the same pathway as DSEL, enhancing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, which is involved in the regulation of numerous proteins through phosphorylation. Inhibition of GSK-3β may stabilize proteins within signaling pathways that enhance DSEL activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases (SAPKs) such as JNK, which can lead to the phosphorylation of proteins within DSEL's pathway, thus enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of PKC, which phosphorylates a multitude of proteins. Through PKC's broad range of targets, DSEL activity could be enhanced due to changes in phosphorylation status within its pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells, which can enhance the activation of PKA and PKG, respectively, potentially enhancing DSEL activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
As a second messenger, cAMP directly activates PKA. PKA can then phosphorylate proteins within the signaling pathways that DSEL is involved in, leading to an enhancement of its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of many proteins. This can indirectly enhance the activity of DSEL through the sustained activation of its pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium levels, which can activate calcium-dependent kinases such as calmodulin-dependent kinases, potentially enhancing DSEL activity through calcium signaling pathways. | ||||||